Evolution and pathogenesis of Leptospira spp.: lessons learned from the genomes

被引：30

作者：

Xue, Feng ^{[1
,2
]}

Yan, Jie ^{[1
,2
]}

Picardeau, Mathieu ^{[3
]}

机构：

[1] Zhejiang Univ, Div Basic Med Microbiol, State Key Lab Diag & Treatment Infect Dis, Affiliated Hosp 1,Med Coll, Hangzhou 310058, Zhejiang, Peoples R China

[2] Zhejiang Univ, Coll Med, Dept Med Microbiol & Parasitol, Hangzhou 310058, Zhejiang, Peoples R China

[3] Inst Pasteur, Unite Biol Spirochetes, F-75724 Paris 15, France

来源：

MICROBES AND INFECTION | 2009年 / 11卷 / 03期

关键词：

Leptospira spp; Comparative genomics; Evolution; Pathogenesis; INTERROGANS SEROVAR LAI; OUTER-MEMBRANE PROTEINS; PROTEOMIC ANALYSIS; STRAINS; IRON; LIPOPOLYSACCHARIDE; MUTAGENESIS; INDUCTION; VIRULENCE; INSIGHTS;

D O I：

10.1016/j.micinf.2008.12.007

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Leptospirosis has emerged to become a major public health problem in developing countries. The availability of complete sequences of strains representing saprophytic and pathogenic species of the genus Leptospira is providing insights into the evolution of virulence and survival mechanisms used by these bacteria to persist in different ecological niches. (C) 2008 Elsevier Masson SAS. All rights reserved.

引用

页码：328 / 333

页数：6

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