Logic Gates Based on DNA Aptamers

被引:13
|
作者
Andrianova, Mariia [1 ]
Kuznetsov, Alexander [1 ]
机构
[1] Sci Mfg Complex Technol Ctr, 1-7 Shokin Sq, Moscow 124498, Russia
关键词
aptamer; logic gate; sensor; biosensor; SINGLE-STRANDED-DNA; CONTROLLED BIOFUEL CELLS; LATERAL FLOW BIOSENSOR; IN-VITRO SELECTION; LABEL-FREE; COLORIMETRIC DETECTION; SMALL MOLECULES; GROWTH-FACTOR; OLIGONUCLEOTIDE INHIBITORS; FUNCTIONALIZED GRAPHENE;
D O I
10.3390/ph13110417
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
DNA bio-computing is an emerging trend in modern science that is based on interactions among biomolecules. Special types of DNAs are aptamers that are capable of selectively forming complexes with target compounds. This review is devoted to a discussion of logic gates based on aptamers for the purposes of medicine and analytical chemistry. The review considers different approaches to the creation of logic gates and identifies the general algorithms of their creation, as well as describes the methods of obtaining an output signal which can be divided into optical and electrochemical. Aptameric logic gates based on DNA origami and DNA nanorobots are also shown. The information presented in this article can be useful when creating new logic gates using existing aptamers and aptamers that will be selected in the future.
引用
收藏
页码:1 / 49
页数:49
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