A DMAP-catalyzed mild and efficient synthesis of 1,2-dihydroquinazolines via a one-pot three-component protocol

被引：39
|
作者：
Derabli, Chamseddine [1 ]
Boulcina, Raouf [1 ]
Kirsch, Gilbert [2 ]
Carboni, Bertrand [3 ]
Debache, Abdelmadjid [1 ]
机构：
[1] Univ Constantine 1, Lab Synth Mol Interets Biol, Constantine 25000, Algeria
[2] Univ Lorraine, SRSMC Site Messin UMR 6575, F-57070 Metz, France
[3] Univ Rennes 1, CNRS, UMR 6226, Sci Chim Rennes, F-35042 Rennes, France
来源：
TETRAHEDRON LETTERS | 2014年 / 55卷 / 01期
关键词：
Multicomponent reaction; 1,2-Dihydroquinazolines; DMAP; 2-Aminobenzophenone; ANTIINFLAMMATORY EVALUATION; QUINAZOLINE DERIVATIVES; PHENYLBORONIC ACID; 2-PHENYLQUINAZOLINES; 1,4-DIHYDROPYRIDINES; CONDENSATION; ALKALOIDS; REAGENTS; DOCKING;
D O I：
10.1016/j.tetlet.2013.10.157
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient and simple method for the synthesis of 1,2-dihydroquinazolines catalyzed by 4-(N,N-dimethylamino)pyridine (DMAP) from readily available aromatic or heteroaromatic aldehydes, 2-aminobenzophenone, and ammonium acetate under mild conditions is described. The scope and limitations of the method are discussed. (C) 2013 Elsevier Ltd. All rights reserved.
引用
收藏
页码：200 / 204
页数：5
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