Rapid Spread and Diversification of Respiratory Syncytial Virus Genotype ON1, Kenya

Respiratory syncytial virus genotype ON1, which is characterized by a 72-nt duplication in the attachment protein gene has been detected in >10 countries, since first identified in Ontario, Canada, in 2010. We describe 2 waves of genotype ON1 infections among, children admitted to a rural hospital in Kenya during 2012. Phylogenetic analysis of attachment protein gene sequences showed multiple, introductions of genotype ON1; variants distinct from the original Canadian viruses predominated in both infection. waves. The genotype ON1 dominated. over the other group, A genotypes during the second, wave, and some first wave ON1 variants reappeared in the second wave. An analysis of global genotype. ON1 sequences determined that this genotype has become considerably diversified and has acquired signature coding mutations within immunogenic regions, and its most recent common ancestor dates to approximate to 2008-2009, Surveillance of genotype ON1 contributes to an understanding of the mechanisms. of rapid, emergence of respiratory viruses.