A preparative chiral separation of hydroxychloroquine using supercritical fluid chromatography

被引：8
|
作者：
Wilson, Laura J. [1 ]
Mi, Charles [2 ]
Kraml, Christina M. [1 ]
机构：
[1] Princeton Univ, Lotus Separat LLC, Princeton, NJ 08540 USA
[2] ColumnTek, 200 Innovat Blvd,STE 258A, State Coll, PA 16801 USA
来源：
JOURNAL OF CHROMATOGRAPHY A | 2020年 / 1634卷
关键词：
SFC; Hydroxychloroquine; Chiral preparative separation; Covid-19; Enantiocel C2-5;
D O I：
10.1016/j.chroma.2020.461661
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
A robust supercritical chromatography (SFC) method using an Enantiocel C2-5 column was developed for the multigram separation of the enantiomers of hydroxychloroquine (HCQ), affirming its use as a scalable technology and ability to provide quantities of each enantiomer for clinical evaluation. The enantiomers of HCQ were collected on a gram scale with greater than 99% enantiomeric excess. The S and R enantiomer elution order was confirmed using optical rotation determinations with comparison to previously determined assignments. (C) 2020 Elsevier B.V. All rights reserved.
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页数：4
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