Isolated Lung Perfusion for Pulmonary Metastases

被引：6
|
作者：
Ward, Alison [1 ]
Prokrym, Kirill [1 ]
Pass, Harvey [1 ]
机构：
[1] NYU, Langone Med Ctr, Dept Cardiothorac Surg, New York, NY 10016 USA
来源：
THORACIC SURGERY CLINICS | 2016年 / 26卷 / 01期
关键词：
Isolated lung perfusion; Pulmonary metastasis; Pulmonary artery perfusion; Chemotherapy; BLOOD-FLOW OCCLUSION; HIGH-DOSE CISPLATIN; VIVO PIG MODEL; ARTERY PERFUSION; NEOADJUVANT THERAPY; SARCOMA MODEL; PHARMACOKINETICS; GEMCITABINE; CHEMOTHERAPY; HYPERTHERMIA;
D O I：
10.1016/j.thorsurg.2015.09.008
中图分类号：
R56 [呼吸系及胸部疾病];
学科分类号：
摘要：
Isolated lung perfusion (ILP) is a surgical technique developed to treat pulmonary metastases. During ILP, high-dose chemotherapy is delivered into the pulmonary vasculature, minimizing systemic exposure and delivering the chemotherapeutic agent directly to the lung. ILP has been studied extensively in a variety of animal models and in humans in phase I trials. The most frequently studied chemotherapeutic agents used in ILP are doxorubicin, 5-flurodeoxyuridine, tumor necrosis factor-alpha, paclitaxel, melphalan, gemcitabine, and cisplatin. Phase I clinical trials with ILP have shown that ILP can be safely performed in humans but with mixed clinical results and poor longterm survival.
引用
收藏
页码：55 / +
页数：15
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