Isolated Lung Perfusion for Pulmonary Metastases

被引：6

作者：

Ward, Alison ^{[1
]}

Prokrym, Kirill ^{[1
]}

Pass, Harvey ^{[1
]}

机构：

[1] NYU, Langone Med Ctr, Dept Cardiothorac Surg, New York, NY 10016 USA

来源：

THORACIC SURGERY CLINICS | 2016年 / 26卷 / 01期

关键词：

Isolated lung perfusion; Pulmonary metastasis; Pulmonary artery perfusion; Chemotherapy; BLOOD-FLOW OCCLUSION; HIGH-DOSE CISPLATIN; VIVO PIG MODEL; ARTERY PERFUSION; NEOADJUVANT THERAPY; SARCOMA MODEL; PHARMACOKINETICS; GEMCITABINE; CHEMOTHERAPY; HYPERTHERMIA;

D O I：

10.1016/j.thorsurg.2015.09.008

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

Isolated lung perfusion (ILP) is a surgical technique developed to treat pulmonary metastases. During ILP, high-dose chemotherapy is delivered into the pulmonary vasculature, minimizing systemic exposure and delivering the chemotherapeutic agent directly to the lung. ILP has been studied extensively in a variety of animal models and in humans in phase I trials. The most frequently studied chemotherapeutic agents used in ILP are doxorubicin, 5-flurodeoxyuridine, tumor necrosis factor-alpha, paclitaxel, melphalan, gemcitabine, and cisplatin. Phase I clinical trials with ILP have shown that ILP can be safely performed in humans but with mixed clinical results and poor longterm survival.

引用

页码：55 / +

页数：15

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