General linear models for multicenter clinical trials

被引：15
|
作者：
Schwemer, G [1 ]
机构：
[1] Chiron Corp, Emeryville, CA 94608 USA
来源：
CONTROLLED CLINICAL TRIALS | 2000年 / 21卷 / 01期
关键词：
multicenter; GLM; pooling; interaction;
D O I：
10.1016/S0197-2456(99)00035-5
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
The use of generalized linear models (GLM) in the analysis of multicenter clinical trials is commonplace. Currently, diverse opinion exists as to the proper modeling approach in this setting. This paper provides a description of the technical backdrop underlying the model selection and discusses the pros and cons of the usual parameter estimators. Arguments are given favoring a model incorporating a term for interaction effect while attenuating the effects of small centers. Control Clin Trials 2000;21:21-29 (C) Elsevier Science Inc. 2000.
引用
收藏
页码：21 / 29
页数：9
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