The multidrug resistance protein family

被引：535
|
作者：
Borst, P
Evers, R
Kool, M
Wijnholds, J
机构：
[1] Netherlands Canc Inst, Div Mol Biol, NL-1066 CX Amsterdam, Netherlands
[2] Netherlands Canc Inst, Ctr Biomed Genet, NL-1066 CX Amsterdam, Netherlands
来源：
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES | 1999年 / 1461卷 / 02期
关键词：
multidrug resistance protein; multidrug resistance; protein routing; glutathione-drug conjugate pump; GSH; cisplatin;
D O I：
10.1016/S0005-2736(99)00167-4
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The human multidrug resistance protein (MRP) family contains at least six members: MRP1, the godfather of the family and well known as the multidrug resistance protein, and five homologs, called MRP2-6. In this review, we summarize what is known about the protein structure, the expression in tissues, the routing in cells, the physiological functions, the substrate specificity, and the role in multidrug resistance of the individual members of the MRP family. (C) 1999 Elsevier Science B.V. All rights reserved.
引用
收藏
页码：347 / 357
页数：11
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