Effects of fasudil on hypoxic pulmonary hypertension and pulmonary vascular remodeling in rats

被引：5
|
作者：
Sun, X. -Z. [1 ]
Tian, X. -Y. [2 ]
Wang, D. -W. [3 ]
Li, J. [3 ]
机构：
[1] Nanjing Med Univ, Huaian Peoples Hosp 1, Dept Pediat, Huaian, Peoples R China
[2] Nanjing Med Univ, Huaian Peoples Hosp 1, Dept Neurol, Huaian, Peoples R China
[3] Nanjing Med Univ, Affiliated Nanjing Childrens Hosp, Dept Cardiol, Nanjing, Jiangsu, Peoples R China
来源：
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES | 2014年 / 18卷 / 07期
关键词：
Fasudil; Pulmonary arterial hypertension (PAH); Pulmonary vascular remodeling; RHO-KINASE INHIBITOR; THERAPEUTIC TARGET;
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
AIM: The aim of this study was to investigate the effects of Rho kinase inhibitor-Fasudil on hypoxic pulmonary hypertension (HPH) and pulmonary vascular remodeling in rats. MATERIALS AND METHODS: A total of 24 Sprague Dawley rats were evenly randomized into control, model and Fasudil intervention groups. Light and transmission electron microscopy were utilized to observe pulmonary vascular remodeling as well as ultrastructural changes in pulmonary arteriole endothelial cells. RESULTS: The model group showed apparent pulmonary vascular remodeling, pulmonary arteriole endothelial cell injury, the proliferation and swelling of smooth muscle cells around, and the proliferation of collagen fibers. Fasudil intervention improved pulmonary vascular remodeling as well as relieved pulmonary arteriole endothelial cell injury and the proliferation of smooth muscle cells and collagen fibers. CONCLUSIONS: Fasudil has preventive and reverse effects on HPH, pulmonary vascular remodeling, and pulmonary arteriole endothelial cell injury.
引用
下载
收藏
页码：959 / 964
页数：6
相关论文
共 50 条
  • [31] Effects of hydrogen sulfide on hypoxic pulmonary vascular structural remodeling
    Jin, HF
    Cong, BL
    Zhao, B
    Zhang, CY
    Liu, XM
    Zhou, WJ
    Shi, Y
    Tang, CS
    Du, JB
    LIFE SCIENCES, 2006, 78 (12) : 1299 - 1309
  • [32] Effects of sulfur dioxide on hypoxic pulmonary vascular structural remodeling
    Sun, Yan
    Tian, Yue
    Prabha, Mainali
    Liu, Die
    Chen, Stella
    Zhang, Rongyuan
    Liu, Xueqin
    Tang, Chaoshu
    Tang, Xiuying
    Jin, Hongfang
    Du, Junbao
    LABORATORY INVESTIGATION, 2010, 90 (01) : 68 - 82
  • [33] Comparison of pulmonary vascular function and structure in early and established hypoxic pulmonary hypertension in rats
    Jeffery, TK
    Wanstall, JC
    CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, 2001, 79 (03) : 227 - 237
  • [34] Effects of iptakalim hydrochloride, a novel KATP channel opener, on pulmonary vascular remodeling in hypoxic rats
    Xie, WP
    Wang, H
    Wang, H
    Hu, G
    LIFE SCIENCES, 2004, 75 (17) : 2065 - 2076
  • [35] The role of endogenous carbon monoxide in the hypoxic vascular remodeling of rat model of hypoxic pulmonary hypertension
    Zhen, Guohua
    Zhang, Zhenxiang
    Xu, Yongjian
    Journal of Huazhong University of Science and Technology - Medical Science, 2003, 23 (04): : 356 - 358
  • [36] The Role of Endogenous Carbon Monoxide in the Hypoxic Vascular Remodeling of Rat Model of Hypoxic Pulmonary Hypertension
    甄国华
    张珍祥
    徐永健
    Current Medical Science, 2003, (04) : 356 - 358
  • [37] Angiotensin II receptor subtypes and pulmonary vascular remodeling during development of hypoxic pulmonary arterial hypertension
    Chassagne, C
    Eddahibi, S
    Adamy, C
    Samuel, JL
    Teiger, E
    CIRCULATION, 1998, 98 (17) : 271 - 271
  • [38] Melatonin Attenuates Dasatinib-Aggravated Hypoxic Pulmonary Hypertension via Inhibiting Pulmonary Vascular Remodeling
    Wang, Rui
    Pan, Jinjin
    Han, Jinzhen
    Gong, Miaomiao
    Liu, Liang
    Zhang, Yunlong
    Liu, Ying
    Wang, Dingyou
    Tang, Qing
    Wu, Na
    Wang, Lin
    Yan, Jinsong
    Li, Hua
    Yuan, Yuhui
    FRONTIERS IN CARDIOVASCULAR MEDICINE, 2022, 9
  • [39] The role of endogenous carbon monoxide in the hypoxic vascular remodeling of rat model of hypoxic pulmonary hypertension
    Zhen Guohua
    Zhang Zhenxiang
    Xu Yongjian
    Current Medical Science, 2003, 23 (4) : 356 - 358
  • [40] CENPE contributes to pulmonary vascular remodeling in pulmonary hypertension
    Fang, Xiaoyu
    Xie, Min
    Liu, Xiansheng
    He, Yuanzhou
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2021, 557 : 40 - 47
12345