The PAI-1 4G/5G and ACE I/D Polymorphisms and Risk of Recurrent Pregnancy Loss: A Case-Control Study

被引：21
|
作者：
Kim, Jin Ju [1 ,2 ]
Choi, Young Min [2 ,3 ]
Lee, Sung Ki [4 ]
Yang, Kwang Moon [5 ,6 ]
Paik, Eun Chan [7 ]
Jeong, Hyeon Jeong [8 ]
Jun, Jong Kwan [3 ]
Han, Ae Ra [9 ]
Hong, Min A. [3 ]
机构：
[1] Seoul Natl Univ Hosp, Healthcare Syst Gangnam Ctr, Dept Obstet & Gynecol, Seoul 110744, South Korea
[2] Seoul Natl Univ, Inst Reprod Med & Populat, Med Res Ctr, Coll Med, Seoul 110744, South Korea
[3] Seoul Natl Univ, Coll Med, Dept Obstet & Gynecol, Seoul 110744, South Korea
[4] Konyang Univ, Dept Obstet & Gynecol, Coll Med, Taejon, South Korea
[5] Kwandong Univ, Cheil Gen Hosp, Dept Obstet & Gynecol, Coll Med, Seoul, South Korea
[6] Kwandong Univ, Coll Med, Womens Healthcare Ctr, Seoul, South Korea
[7] Bundangcheil Womens Hosp, Dept Obstet & Gynecol, Bundang, South Korea
[8] Seoul Rachel Fertil Ctr, Dept Obstet & Gynecol, Seoul, South Korea
[9] Kyungpook Natl Univ, Dept Obstet & Gynecol, Coll Med, Taegu, South Korea
来源：
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY | 2014年 / 72卷 / 06期
关键词：
Angiotensin converting enzyme; plasminogen activator inhibitor type 1; recurrent pregnancy loss; single-nucleotide polymorphisms; PLASMINOGEN-ACTIVATOR INHIBITOR-1; ANGIOTENSIN-CONVERTING ENZYME; GENETIC ASSOCIATION; MISCARRIAGE; WOMEN; EXPRESSION; GENOTYPE; SYSTEM;
D O I：
10.1111/aji.12302
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
ProblemThrombophilia has been postulated to be a contributor to the pathophysiology of recurrent pregnancy loss (RPL). We investigated the role of the plasminogen activator inhibitor type 1 (PAI-1) 4G/5G and angiotensin converting enzyme (ACE) I/D polymorphisms in Korean patients with RPL. Method of studyGenotyping was performed using the TaqMan assay in 227 RPL patients and 304 controls. ResultsThe genotype distributions of both polymorphisms in the RPL group did not differ from those of controls. Because the frequency of being homozygous for ACE D/D and the PAI-I 4G/4G combination has been reported to be significantly higher in RPL patients, this was also analyzed. However, no significant difference was noted; 3.1% of RPL patients had both ACE D/D and PAI-I 4G/4G, as did 4.9% of controls (P=0.791). ConclusionThe current study suggests that both polymorphisms, either alone or in combination, are not major determinants of the development of RPL in Korean women.
引用
收藏
页码：571 / 576
页数：6
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