Microwave-Assisted, Solvent-Free Synthesis of 3′-(Aryl/Heteroaryl)-1-morpholinomethyl/piperidinomethylspiro[3H-indole-3,2′-thiazolidine]-2,4′(1H)-diones via 3-Isatinimines

被引：13
|
作者：
Pandey, Manju [1 ]
Raghuvanshi, Dushyant Singh [1 ]
Singh, Krishna Nand [1 ]
机构：
[1] Banaras Hindu Univ, Dept Chem, Varanasi 221005, Uttar Pradesh, India
来源：
JOURNAL OF HETEROCYCLIC CHEMISTRY | 2009年 / 46卷 / 01期
关键词：
ORGANIC-SYNTHESIS; IRRADIATION; IMINES; CLAY;
D O I：
10.1002/jhet.12
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The solvent-free, microwave (MW)-assisted synthesis of a new series of 3'-(aryl/heteroaryl)-1-morpholinomethyl/piperidinomethylspiro[3H-indole-3,2'-thiazolidine]-2,4'(1H)-diones has been achieved in an open vessel. Isatins 1 undergo an easy condensation with various aryl/heteroaryl at-nines by MW using montmorillonite K10 clay as a solid support to afford Schiff bases 2, which subsequently undergo smooth cyclization with TGA under neat MW conditions to afford the spiro thiazolidinones 3. The spiro-compounds are made to react with rnorpholine/piperidine and formaldehyde to give the corresponding Mannich bases 4/5 in reasonably good yield.
引用
收藏
页码：49 / 53
页数：5
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