Environmental enrichment restores CA1 hippocampal LTP and reduces severity of seizures in epileptic mice

被引：21

作者：

Morelli, Emanuela ^{[1
,2
]}

Ghiglieri, Veronica ^{[1
]}

Pendolino, Valentina ^{[1
]}

Bagetta, Vincenza ^{[1
]}

Pignataro, Annabella ^{[3
]}

Fejtova, Anna ^{[4
]}

Costa, Cinzia ^{[5
]}

Ammassari-Teule, Martine ^{[3
]}

Gundelfinger, Eckart D. ^{[4
]}

Picconi, Barbara ^{[1
]}

Calabresi, Paolo ^{[1
,5
]}

机构：

[1] IRCCS, Neurophysiol Lab, Fdn Santa Lucia, Rome, Italy

[2] Ist Seraf, Perugia, Italy

[3] IRCCS, Psychobiol Lab, Fdn Santa Lucia, Rome, Italy

[4] Leibniz Inst Neurobiol, Magdeburg, Germany

[5] Univ Perugia, Osped S Maria Misericordia, Neurol Clin, I-06100 Perugia, Italy

来源：

EXPERIMENTAL NEUROLOGY | 2014年 / 261卷

关键词：

Synaptic plasticity; Hippocampus; Bassoon; Epilepsy; Neurodevelopmental disorder; Environmental enrichment; LONG-TERM POTENTIATION; BASSOON-MUTANT MICE; EXPERIMENTAL PARKINSONS-DISEASE; TEMPORAL-LOBE EPILEPSY; PROTEIN BASSOON; MORPHOLOGICAL ANALYSIS; SYNAPTIC STRENGTH; SILENT SYNAPSES; ACTIVE ZONE; MOUSE MODEL;

D O I：

10.1016/j.expneurol.2014.05.010

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We have analyzed the effects of environmental enrichment (EE) in a seizure-prone mouse model in which the genetic disruption of the presynaptic protein Bassoon leads to structural and functional alterations in the hippocampus and causes early spontaneous seizures mimicking human neurodevelopmental disorders. One-month EE starting at P21 reduced seizure severity, preserved long-term potentiation (LTP) and paired-pulse synaptic responses in the hippocampal CA1 neuronal population and prevented the reduction of spine density and dendrite branching of pyramidal neurons. These data demonstrate that EE exerts its therapeutic effect by normalizing multiple aspects of hippocampal function and provide experimental support for its use in the optimization of existent treatments. (C) 2014 Elsevier Inc. All rights reserved.

引用

页码：320 / 327

页数：8

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