The implementation of e-health system in Latvia healthcare has been initiated since 2003, but for long time there was no success in this area. Therefore this paper analyzes e-health project progress in Latvia, implementation process and current situation. To understand main problems of so problematic e-health implementation, in this paper analyzed national strategic documents and normative documents as well as several informative resources. The last document, approved in 2010 includes 3 project development parts witch should be implemented to year 2013: 1) Electronic health card and integration platform solution information system; 2) Electronic appointment booking system, healthcare workflow digitizing, society health portal; 3) Electronic prescriptions information system. Currently Latvia is at start of e-health implementation second part process for e-health program and systems development. This paper analyzes current status for e-health information system development process as well as discovers main e-health implementation problematic: interoperability, maintenance, legal and regulatory restrictions and security and confidentiality of patient's data. Currently the main topics of the discussion are associated with data security and confidentiality.