Mechanisms of autoimmunity in human diseases: a critical review of current dogma

被引:12
|
作者
Benson, Robert A. [1 ]
Brewer, James M. [1 ]
Platt, Andrew M. [1 ]
机构
[1] Univ Glasgow, Inst Infect Immun & Inflammat, Coll Med Vet & Life Sci, Glasgow G12 8TA, Lanark, Scotland
关键词
antigen presentation; autoimmunity; dendritic cells; self-tolerance; REGULATORY T-CELLS; RHEUMATOID-ARTHRITIS SYNOVIUM; TOLEROGENIC DENDRITIC CELLS; B-CELLS; SELF-TOLERANCE; SUBSETS; ASSOCIATION; THERAPY; ACTIVATION; INHIBITION;
D O I
10.1097/BOR.0000000000000037
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Purpose of reviewAutoimmune diseases such as rheumatoid arthritis (RA) pose an increasing, worldwide economic and health burden. Significantly, no cure exists for the majority of autoimmune diseases and consequently treatment is largely aimed at controlling disease symptoms. Therefore, there exists a critical need to develop new approaches that directly address the cause of disease, leading to disease remission and ultimately cure.Recent findingsThe organs, cells and molecules involved in the breach of self-tolerance have been partially defined in experimental models of autoimmunity. However, the broad applicability of this dogma in clinical disease is only partially understood. This gap between analyses of established disease and investigating early disease pathogenesis argues for the need for complementary studies in mice and humans.SummaryThrough a combination of clinical and experimental systems, novel autoantigens and neoepitopes involved in RA have been revealed. These have clear utility in predisease diagnosis and offer the possibility of antigen-specific immunotherapy. Ongoing experimental and clinical studies, for example using dendritic cell transfer, will facilitate a clearer understanding of the molecules, cells and organs that should be targeted to reinstate immunological tolerance. Antigen-specific immunotherapy therefore offers disease intervention without broad immunosuppression, and most importantly increases the likelihood of achieving true disease remission and cure.
引用
收藏
页码:197 / 203
页数:7
相关论文
共 50 条
  • [21] Bisphenol A and human chronic diseases: Current evidences, possible mechanisms, and future perspectives
    Rezg, Raja
    El-Fazaa, Saloua
    Gharbi, Najoua
    Mornagui, Bessem
    ENVIRONMENT INTERNATIONAL, 2014, 64 : 83 - 90
  • [22] Viruses and Autoimmunity: A Review on the Potential Interaction and Molecular Mechanisms
    Smatti, Maria K.
    Cyprian, Farhan S.
    Nasrallah, Gheyath K.
    Al Thani, Asmaa A.
    Almishal, Ruba O.
    Yassine, Hadi M.
    VIRUSES-BASEL, 2019, 11 (08):
  • [23] Primary Immunodeficiency and Autoimmunity: Lessons From Human Diseases
    Arason, G. J.
    Jorgensen, G. H.
    Ludviksson, B. R.
    SCANDINAVIAN JOURNAL OF IMMUNOLOGY, 2010, 71 (05) : 317 - 328
  • [24] MECHANISMS OF CYTOKINESIS - A CRITICAL REVIEW
    ROBERTS, HS
    QUARTERLY REVIEW OF BIOLOGY, 1961, 36 (03): : 155 - 177
  • [25] Mobility of mechanisms: a critical review
    Gogu, G
    MECHANISM AND MACHINE THEORY, 2005, 40 (09) : 1068 - 1097
  • [26] Treating Human Autoimmunity: Current Practice and Future Prospects
    Rosenblum, Michael D.
    Gratz, Iris K.
    Paw, Jonathan S.
    Abbas, Abul K.
    SCIENCE TRANSLATIONAL MEDICINE, 2012, 4 (125)
  • [27] Mechanisms of altered protein turnover in chronic diseases: a review of human kinetic studies
    Biolo, G
    Antonione, R
    Barazzoni, R
    Zanetti, M
    Guarnieri, G
    CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE, 2003, 6 (01): : 55 - 63
  • [28] Peptide-MHC-Based Nanomedicines for the Treatment of Autoimmunity: Engineering, Mechanisms, and Diseases
    Serra, Pau
    Santamaria, Pere
    FRONTIERS IN IMMUNOLOGY, 2021, 11
  • [29] Diseases of the kidney: Molecular mechanisms and current therapy
    Hsu, SIH
    CURRENT MOLECULAR MEDICINE, 2005, 5 (05) : 453 - 454
  • [30] Molecular mechanisms mediated by Human Endogenous Retroviruses (HERVs) in autoimmunity
    Balada, Eva
    Ordi-Ros, Josep
    Vilardell-Tarres, Miquel
    REVIEWS IN MEDICAL VIROLOGY, 2009, 19 (05) : 273 - 286