Intrinsically fluorescent hollow spheres based on organic-inorganic hybrid polyphosphazene material: Synthesis and application in drug release

被引：41
|
作者：
Chang, Fuqiang [1 ]
Huang, Xiaobin [2 ]
Wei, Hao [3 ]
Chen, Kuiyong [1 ]
Shan, Congcong [1 ]
Tang, Xiaozhen [4 ]
机构：
[1] Shanghai Jiao Tong Univ, Sch Chem & Chem Engn, Shanghai 200240, Peoples R China
[2] Shanghai Jiao Tong Univ, Minist Educ, Sch Chem & Chem Engn, Key Lab Thin Film & Microfabricat Technol, Shanghai 200240, Peoples R China
[3] Shanghai Jiao Tong Univ, Inst Micro Nano Sci & Technol, Minist Educ, Key Lab Thin Film & Microfabricat Technol, Shanghai 200240, Peoples R China
[4] Shanghai Jiao Tong Univ, Sch Chem & Chem Engn, Natl Key Lab Metall Matrix Composite Mat, Shanghai 200240, Peoples R China
来源：
MATERIALS LETTERS | 2014年 / 125卷
基金：
中国国家自然科学基金;
关键词：
Functional; Resveratrol; Hollow spheres; Controlled release; Nanoparticles; MICROSPHERES; PRECIPITATION; NANOPARTICLES; STABILITY;
D O I：
10.1016/j.matlet.2014.03.137
中图分类号：
T [工业技术];
学科分类号：
08 ;
摘要：
Highly cross-linked organic-inorganic hybrid porous poly [(cyclotriphosphazene-co-resveratro)] spheres with hollow structure were prepared via precipitation polymerization of hexachlorocyclotriphosphazene and resveratrol. Poly [(cyclotriphosphazene-co-resveratro)] spheres mesoporous hollow spheres with resveratrol structures maintained intrinsical fluorescence and outstanding dispersability in both aqueous and organic media for their abundant functional groups. Besides, these cross-linked polyphosphazene spheres manifested high drug storage capacity and remarkable sustained release property. Moreover, the release rate of the drug from polyphosphazene microspheres was greatly dependent on pH value with resveratrol as a model molecule. (C) 2014 Elsevier B.V. All rights reserved.
引用
收藏
页码：128 / 131
页数：4
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