Reducing glycosphingolipid content in adipose tissue of obese mice restores insulin sensitivity, adipogenesis and reduces inflammation

被引:0
|
作者
van Eijk, Marco [1 ]
Aten, Jan [2 ]
Biji, Nora [1 ]
Ottenhoff, Roelof [1 ]
van Roomen, Cindy P. A. A. [1 ]
Dubbelhuis, Peter F. [1 ]
Seeman, Ingar [1 ]
Ghauharali-van der Vlugt, Karen [1 ]
Overkleeft, Hermen S. [3 ]
Arbeeny, Cynthia [4 ]
Groen, Albert K. [1 ]
Aerts, Johannes M. F. G. [1 ]
机构
[1] Univ Amsterdam, Acad Med Ctr, Dept Med Biochem, NL-1105 AZ Amsterdam, Netherlands
[2] Univ Amsterdam, Acad Med Ctr, Dept Pathol, NL-1105 AZ Amsterdam, Netherlands
[3] Leiden Univ, Dept Organ Chem, Gorleaus Inst, NL-2300 RA Leiden, Netherlands
[4] Genzyme Corp, Framingham, MA 01701 USA
关键词
D O I
10.1016/j.chemphyslip.2009.06.130
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
引用
收藏
页码:S14 / S14
页数:1
相关论文
共 50 条
  • [31] Resveratrol Improves Insulin Sensitivity in Concert With Reduced Inflammation and "Browning" of White Adipose Tissue in Obese, Insulin Resistant Humans
    Raghavan, Pooja
    Maginley, Roger
    Zhang, Kehao
    Milne, Ginger L.
    Kim, Charles
    Esterson, Yonah B.
    Carey, Michelle
    Crandall, Jill
    Tomuta, Nora
    Kishore, Preeti
    Hawkins, Meredith
    DIABETES, 2013, 62 : A25 - A25
  • [32] VITAMIN D ADMINISTRATION IMPROVES HEPATIC INSULIN SENSITIVITY AND ADIPOSE TISSUE INFLAMMATION IN OBESE, INSULIN RESISTANT HUMANS.
    Goyal, Akankasha
    Carey, Michelle
    Maginley, Roger
    Reda, Sarah
    Hawkins, Meredith
    Kishore, Preeti
    JOURNAL OF INVESTIGATIVE MEDICINE, 2014, 62 (04) : 771 - 771
  • [33] Repin1 deficiency improves insulin sensitivity and glucose metabolism in db/db mice by reducing adipose tissue mass and inflammation
    Kunath, Anne
    Hesselbarth, Nico
    Gericke, Martin
    Kern, Matthias
    Dommel, Sebastian
    Kovacs, Peter
    Stumvoll, Michael
    Bluether, Matthias
    Kloeting, Nora
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2016, 478 (01) : 398 - 402
  • [34] EFFECT OF INSULIN IN VIVO ON DIAPHRAGM AND ADIPOSE TISSUE OF OBESE MICE
    STAUFFACHER, W
    RENOLD, AE
    AMERICAN JOURNAL OF PHYSIOLOGY, 1969, 216 (01): : 98 - +
  • [35] Adipose Tissue Inflammation and Reduced Insulin Sensitivity in Ovariectomized Mice Occurs in the Absence of Increased Adiposity
    Potter, Victoria J. Vieira
    Strissel, Katherine J.
    Xie, Chen
    Chang, Eugene
    Bennett, Grace
    Defuria, Jason
    Obin, Martin S.
    Greenberg, Andrew S.
    ENDOCRINOLOGY, 2012, 153 (09) : 4266 - 4277
  • [36] Adipose tissue transplantation protects ob/ob mice from obesity, normalizes insulin sensitivity and restores fertility
    Klebanov, S
    Astle, CM
    DeSimone, O
    Ablamunits, V
    Harrison, DE
    JOURNAL OF ENDOCRINOLOGY, 2005, 186 (01) : 203 - 211
  • [37] Fermented Soy Product Reduces Adipose Mass, Improves Insulin Sensitivity and Alters Adipose Tissue Gene Products in Mice
    不详
    FASEB JOURNAL, 2008, 22
  • [38] Curative diet supplementation with a melon superoxide dismutase reduces adipose tissue in obese hamsters by improving insulin sensitivity
    Carillon, Julie
    Knabe, Lucie
    Montalban, Anne
    Stevant, Marie
    Keophiphath, Mayoura
    Lacan, Dominique
    Cristol, Jean-Paul
    Rouanet, Jean-Max
    MOLECULAR NUTRITION & FOOD RESEARCH, 2014, 58 (04) : 842 - 850
  • [39] Increased brown fat and insulin sensitivity in obese mice overexpressing WISP2 in the adipose tissue
    Grunberg, J. R.
    Hoffmann, J. M.
    Hedjazifar, S.
    Nerstedt, A.
    Jenndahl, L.
    Castellot, J.
    Wei, L.
    Skrtic, S. Moverare
    Backhed, F.
    Syed, I.
    Saghetelian, A.
    Kahn, B.
    Hammarstedt, A.
    Smith, U.
    DIABETOLOGIA, 2015, 58 : S105 - S106
  • [40] Inducing Young Subcutaneous Adipose Tissue Formation Improves Glucose Tolerance and Insulin Sensitivity in Obese Mice
    Lu, Qiqi
    Li, Mingming
    Zou, Yu
    Cao, Tong
    DIABETES, 2012, 61 : A488 - A488