Prominent auditory deficits in primary progressive aphasia: A case study

被引:12
|
作者
Utianski, Rene L. [1 ]
Duffy, Joseph R. [1 ]
Clark, Heather M. [1 ]
Machulda, Mary M. [2 ]
Dickson, Dennis W. [3 ]
Whitwell, Jennifer L. [4 ]
Josephs, Keith A. [1 ]
机构
[1] Mayo Clin, Dept Neurol, 200 1st St SW, Rochester, MN 55905 USA
[2] Mayo Clin, Dept Psychiat & Psychol, Rochester, MN USA
[3] Mayo Clin, Dept Pathol & Neurol, Jacksonville, FL 32224 USA
[4] Mayo Clin, Dept Radiol, Rochester, MN USA
基金
美国国家卫生研究院;
关键词
Primary progressive aphasia; Auditory agnosia; Frontotemporal dementia; PET; Corticobasal degeneration; PURE WORD DEAFNESS; FRONTOTEMPORAL PATHOLOGY; APRAXIA; SPEECH; CLASSIFICATION; ALZHEIMERS; AGNOSIA; FORM; PATIENT; MRI;
D O I
10.1016/j.cortex.2019.01.021
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
Aphasia typically is associated with comparable difficulties in written and spoken modalities of language expression and comprehension. In contrast, auditory verbal agnosia is the disproportionate difficulty comprehending spoken compared to written language, also typically greater than difficulties with spoken and written language expression, in the absence of a primary sensory deficit. The terms pure word deafness and auditory verbal agnosia are often used synonymously. However, the broader term of auditory agnosia more accurately reflects difficulty processing both speech and non-speech sounds whereas individuals with auditory verbal agnosia (pure word deafness) have preserved processing of environmental sounds. Auditory agnosia is reported in the stroke literature, but rarely reported in progressive neurologic disorders. Here, we report a case of a woman who presented with what is best described as a prominent auditory deficit in the context of an initially unclassifiable, or mixed, primary progressive aphasia (PPA) with accompanying apraxia of speech. Her clinical presentation shared features with auditory agnosia, although sensory functioning was not formally assessed. We report clinical and neuroimaging data spanning 6 years and subsequent autopsy results. She presented at 65 years of age, 5 years post onset of symptoms that included insidious and progressive difficulties thinldng of words, constructing sentences, pronouncing words, and understanding instructions. She had disproportionate difficulty with comprehension of spoken compared to written language. She eventually developed features of the nonfluent/agrammatic variant of PPA, as well as an apraxia of speech. Imaging with [18F]-fluorodeoxyglucose (FDG)-PET revealed progression of bilateral (left greater than right) hypometabolism involving the frontal, temporal (predominantly the lateral superior gyrus), and parietal lobes, that eventually included the supplementary motor area, anterior cingulate, and caudate. Autopsy revealed pathological lesions consistent with corticobasal degeneration. 0 2019 Elsevier Ltd. All rights reserved.
引用
收藏
页码:396 / 406
页数:11
相关论文
共 50 条
  • [41] Delayed auditory feedback simulates features of nonfluent primary progressive aphasia
    Maruta, Carolina
    Makhmood, Sonya
    Downey, Laura E.
    Golden, Hannah L.
    Fletcher, Phillip D.
    Witoonpanich, Pirada
    Rohrer, Jonathan D.
    Warren, Jason D.
    [J]. JOURNAL OF THE NEUROLOGICAL SCIENCES, 2014, 347 (1-2) : 345 - 348
  • [42] Exploring (central) auditory processing deficits in individuals with Broca's aphasia: Based on case study
    Kumar, Prawin
    Mohan, B. Meghana
    Pavithra, K.
    Naveen, C. P.
    [J]. INDIAN JOURNAL OF OTOLOGY, 2016, 22 (02) : 135 - 138
  • [43] Primary progressive aphasia
    Mesulam, MM
    [J]. ANNALS OF NEUROLOGY, 2001, 49 (04) : 425 - 432
  • [44] Primary progressive aphasia
    Kertesz, A
    Munoz, DG
    [J]. CLINICAL NEUROSCIENCE, 1997, 4 (02) : 95 - 102
  • [45] Characterising primary progressive aphasia - a neuropsychological study
    Harris, J.
    Adams, J.
    Jones, M.
    Richardson, A.
    Neary, D.
    Snowden, J.
    Thompson, J.
    [J]. JOURNAL OF NEUROCHEMISTRY, 2016, 138 : 347 - 347
  • [46] PRIMARY PROGRESSIVE APHASIA
    DUFFY, JR
    PETERSEN, RC
    [J]. APHASIOLOGY, 1992, 6 (01) : 1 - 15
  • [47] Primary progressive aphasia
    Csefalvay, Z.
    Bajtosova, R.
    Keller, J.
    Strakova, E.
    Matej, R.
    Rusina, R.
    [J]. CESKA A SLOVENSKA NEUROLOGIE A NEUROCHIRURGIE, 2020, 83 (03) : 226 - 239
  • [48] Primary progressive aphasia
    Kertesz, Andrew
    Harciarek, Michal
    [J]. SCANDINAVIAN JOURNAL OF PSYCHOLOGY, 2014, 55 (03) : 191 - 201
  • [49] Primary progressive aphasia
    Rose, David Z.
    [J]. CLEVELAND CLINIC JOURNAL OF MEDICINE, 2007, 74 (01) : 9 - 9
  • [50] Primary progressive aphasia
    Bekkhus-Wetterberg, Peter
    Mueller, Ebba Gloersen
    Winsnes, Ingvild Elisabeth
    Braekhus, Anne
    Norvik, Monica Irene
    Wyller, Torgeir Bruun
    [J]. TIDSSKRIFT FOR DEN NORSKE LAEGEFORENING, 2022, 142 (17) : 1477 - 1480