Maintenance of Viral Suppression in Human Immunodeficiency Virus Controllers Despite Waning T-Cell Responses During Antiretroviral Therapy

被引：3

作者：

Jilg, Nikolaus ^{[1
]}

Garcia-Broncano, Pilar ^{[2
]}

Peluso, Michael ^{[3
]}

Segal, Florencia P. ^{[4
]}

Bosch, Ronald J. ^{[5
]}

Roberts-Toler, Carla ^{[5
]}

Chen, Samantha M. Y. ^{[2
]}

Van Dam, Cornelius N. ^{[6
]}

Keefer, Michael C. ^{[7
]}

Kuritzkes, Daniel R. ^{[4
]}

Landay, Alan L. ^{[8
]}

Deeks, Steven ^{[3
]}

Yu, Xu G. ^{[2
]}

Sax, Paul E. ^{[4
]}

Li, Jonathan Z. ^{[4
]}

机构：

[1] Harvard Med Sch, Massachusetts Gen Hosp, Boston, MA 02115 USA

[2] Ragon Inst MGH MIT & Harvard, Cambridge, MA USA

[3] Univ Calif San Francisco, San Francisco, CA 94143 USA

[4] Harvard Med Sch, Brigham & Womens Hosp, Boston, MA 02115 USA

[5] Harvard TH Chan Sch Publ Hlth, Boston, MA USA

[6] Univ N Carolina, Greensboro, NC USA

[7] Univ Rochester, Sch Med & Dent, Rochester, NY USA

[8] Rush Univ, Med Ctr, Chicago, IL USA

来源：

JOURNAL OF INFECTIOUS DISEASES | 2020年 / 222卷 / 11期

基金：

美国国家卫生研究院;

关键词：

HIV controllers; elite controllers; viremic control; antiretroviral therapy; treatment interruption; T-cell response;

D O I：

10.1093/infdis/jiaa294

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

AIDS Clinical Trials Group study A5308 found reduced T-cell activation and exhaustion in human immunodeficiency virus (HIV) controllers start antiretroviral therapy (ART). We further assessed HIV-specific T-cell responses and post-ART viral loads. Before ART, the 31% of participants with persistently undetectable viremia had more robust HIV-specific T-cell responses. During ART, significant decreases were observed in a broad range of T-cell responses. Eight controllers in A5308 and the Study of the Consequences of the Protease Inhibitor Era (SCOPE) cohort showed no viremia above the level of quantification in the first 12 weeks after ART discontinuation. ART significantly reduced HIV-specific T-cell responses in HIV controllers but did not adversely affect controller status after ART discontinuation.

引用

页码：1837 / 1842

页数：6

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