Discovery of 2′-hydroxychalcones as autophagy inducer in A549 lung cancer cells

被引：17
|
作者：
Wang, Fang-Wu [1 ]
Wang, Sheng-Qing [2 ]
Zhao, Bao-Xiang [2 ]
Miao, Jun-Ying [1 ]
机构：
[1] Shandong Univ, Sch Life Sci, Inst Dev Biol, Jinan 250100, Peoples R China
[2] Shandong Univ, Sch Chem & Chem Engn, Inst Organ Chem, Jinan 250100, Peoples R China
来源：
ORGANIC & BIOMOLECULAR CHEMISTRY | 2014年 / 12卷 / 19期
基金：
中国国家自然科学基金;
关键词：
ENDOPLASMIC-RETICULUM STRESS; PROSTATE-CANCER; MOLECULAR-MECHANISMS; APOPTOSIS INDUCER; MAMMALIAN TARGET; IN-VITRO; DERIVATIVES; INHIBITION; CHALCONE; PATHWAY;
D O I：
10.1039/c3ob42429d
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A series of 2'-hydroxychalcone derivatives was synthesized and the effects of all the compounds on growth of A549 lung cancer cell were investigated. The results showed that all compounds had inhibitory effects on the growth of A549 lung cancer cells and compound 2-7 possessed the highest growth inhibitory effect and induced autophagy of A549 lung cancer cells.
引用
收藏
页码：3062 / 3070
页数：9
相关论文
共 50 条
  • [31] Characterization of a stem cell population in lung cancer A549 cells
    Sung, Ji-Min
    Cho, Hee-Jung
    Yi, Hee
    Lee, Chi-Ho
    Kim, Hye-Sun
    Kim, Dong-Ku
    Ei-Aty, A. M. Abd
    Kim, Jin-Suk
    Landowski, Christopher P.
    Hediger, Matthias A.
    Shin, Ho-Chul
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2008, 371 (01) : 163 - 167
  • [32] Exosomes: Decreased Sensitivity of Lung Cancer A549 Cells to Cisplatin
    Xiao, Xia
    Yu, Shaorong
    Li, Shuchun
    Wu, Jianzhong
    Ma, Rong
    Cao, Haixia
    Zhu, Yanliang
    Feng, Jifeng
    PLOS ONE, 2014, 9 (02):
  • [33] Effects of trifluoperazine analogue on A549 human lung cancer cells
    Jeong, Joo Yeon
    Ryu, Jinhyun
    Yoon, Nal Ae
    Kang, Seokmin
    Seong, Hyemin
    Fudhaili, Ahmad
    Park, Juyeong
    Sim, Jimin
    Lee, Jiyeon
    Hwang, Soohyun
    Kang, Sang Soo
    CANCER RESEARCH, 2017, 77
  • [34] LIPOFECTAMIN 2000 MEDIATED RBM5 OVEREXPRESSION INDUCES AUTOPHAGY IN HUMAN LUNG CANCER A549 CELLS
    Zhang, Jie
    Su, Zhenzhong
    Wang, Ke
    Lv, Xuejiao
    Hao, Yuqiu
    Wang, Qi
    Meng, Guangping
    RESPIROLOGY, 2014, 19 : 159 - 159
  • [35] Inhibiting Autophagy Promotes Cisplatin-Induced Apoptotic Cell Death In A549 Human Lung Cancer Cells
    Zhang, L.
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2016, 193
  • [36] Feroniellin A- induced autophagy causes apoptosis in multidrug- resistant human A549 lung cancer cells
    Kaewpiboon, Chutima
    Surapinit, Serm
    Malilas, Waraporn
    Moon, Jeong
    Phuwapraisirisan, Preecha
    Tip-Pyang, Santi
    Johnston, Randal N.
    Koh, Sang Seok
    Assavalapsakul, Wanchai
    Chung, Young-hwa
    INTERNATIONAL JOURNAL OF ONCOLOGY, 2014, 44 (04) : 1233 - 1242
  • [37] Psoralidin induces autophagy through ROS generation which inhibits the proliferation of human lung cancer A549 cells
    Hao, Wenhui
    Zhang, Xuenong
    Zhao, Wenwen
    Chen, Xiuping
    PEERJ, 2014, 2
  • [38] Modified Panax ginseng extract regulates autophagy by AMPK signaling in A549 human lung cancer cells.
    Eunbi, J.
    Kang, S.
    Jang, I.
    MOLECULAR BIOLOGY OF THE CELL, 2016, 27
  • [39] The Interplay between Autophagy and Apoptosis Induced by One Synthetic Curcumin Derivative Hydrazinobenzoylcurcumin in A549 Lung Cancer Cells
    Zhou, Guang-Zhou
    Sun, Gang-Chun
    Zhang, Shuai-Na
    JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY, 2015, 29 (06) : 267 - 273
  • [40] In Silico Discovery of a Small Molecule Suppressing Lung Carcinoma A549 Cells Proliferation and Inducing Autophagy via mTOR Pathway Inhibition
    Liu, Jiyuan
    Liu, Li
    Tian, Zhen
    Li, Yifan
    Shi, Changhong
    Shi, Junling
    Wei, Sanhua
    Zhao, Yong
    Zhang, Caiqing
    Bai, Bing
    Chen, Zhinan
    Zhang, Hai
    MOLECULAR PHARMACEUTICS, 2018, 15 (11) : 5427 - 5436
12345