Discovery of 2′-hydroxychalcones as autophagy inducer in A549 lung cancer cells

被引：17
|
作者：
Wang, Fang-Wu [1 ]
Wang, Sheng-Qing [2 ]
Zhao, Bao-Xiang [2 ]
Miao, Jun-Ying [1 ]
机构：
[1] Shandong Univ, Sch Life Sci, Inst Dev Biol, Jinan 250100, Peoples R China
[2] Shandong Univ, Sch Chem & Chem Engn, Inst Organ Chem, Jinan 250100, Peoples R China
来源：
ORGANIC & BIOMOLECULAR CHEMISTRY | 2014年 / 12卷 / 19期
基金：
中国国家自然科学基金;
关键词：
ENDOPLASMIC-RETICULUM STRESS; PROSTATE-CANCER; MOLECULAR-MECHANISMS; APOPTOSIS INDUCER; MAMMALIAN TARGET; IN-VITRO; DERIVATIVES; INHIBITION; CHALCONE; PATHWAY;
D O I：
10.1039/c3ob42429d
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A series of 2'-hydroxychalcone derivatives was synthesized and the effects of all the compounds on growth of A549 lung cancer cell were investigated. The results showed that all compounds had inhibitory effects on the growth of A549 lung cancer cells and compound 2-7 possessed the highest growth inhibitory effect and induced autophagy of A549 lung cancer cells.
引用
收藏
页码：3062 / 3070
页数：9
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