Whole-Genome Sequencing in Epidemiology of Campylobacter jejuni Infections

被引:5
|
作者
Llarena, Ann-Katrin [1 ]
Taboada, Eduardo [2 ]
Rossi, Mirko [1 ]
机构
[1] Univ Helsinki, Dept Food Hyg & Environm Hlth, Fac Vet Med, Helsinki, Finland
[2] Publ Hlth Agcy Canada, Anim Dis Res Inst, Natl Microbiol Lab Lethbridge, Lethbridge, AB, Canada
关键词
foodborne pathogens; genome analysis; molecular subtyping; surveillance studies; OUTBREAK; POPULATION; COLONIZATION; DISEASE; HUMANS; GENES; MLST; WGS;
D O I
10.1128/JCM.00017-17
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
This review describes the current state of knowledge regarding the application of whole-genome sequencing (WGS) in the epidemiology of Campylobacter jejuni, the leading cause of bacterial gastroenteritis worldwide. We describe how WGS has increased our understanding of the evolutionary and epidemiological dynamics of this pathogen and how WGS has the potential to improve surveillance and outbreak detection. We have identified hurdles to the full implementation of WGS in public health settings. Despite these challenges, we think that ample evidence is available to support the benefits of integrating WGS into the routine monitoring of C. jejuni infections and outbreak investigations.
引用
收藏
页码:1269 / 1275
页数:7
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