Asymmetric Michael-Aldol Tandem Reaction of 2-Substituted Benzofuran-3-ones and Enones: A Facile Synthesis of Griseofulvin Analogues

被引：43
|
作者：
Dong, Nan [1 ]
Li, Xin [1 ]
Wang, Feng [1 ]
Cheng, Jin-Pei [1 ]
机构：
[1] Nankai Univ, Dept Chem, State Key Lab Elementoorgan Chem, Tianjin 300071, Peoples R China
来源：
ORGANIC LETTERS | 2013年 / 15卷 / 18期
基金：
中国国家自然科学基金;
关键词：
3-SUBSTITUTED BENZOFURAN-2(3H)-ONES; CHEMICAL STRUCTURE; ADDITION-REACTIONS; DL-GRISEOFULVIN; ORAL TREATMENT; ANTIBIOTICS; DERIVATIVES; RINGWORM;
D O I：
10.1021/ol402346c
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A highly enantioselective Michael aldol tandem reaction with respect to prochiral 2-substituted benzofuran-3-ones and enones by a facile primary amine catalyst was investigated. The approach provides rapid access to the desired pharmaceutically active griseofulvin analogues.
引用
收藏
页码：4896 / 4899
页数：4
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