Signaling pathways of the F11 receptor (F11R; a.k.a. JAM-1, JAM-A) in human platelets: F11R dimerization, phosphorylation and complex formation with the integrin GPIIIa

被引：40
|
作者：
Sobocka, MB
Sobocki, T
Babinska, A
Hartwig, JH
Li, MG
Ehrlich, YH
Kornecki, E
机构：
[1] Suny Downstate Med Ctr, Dept Anat & Cell Biol, Brooklyn, NY 11203 USA
[2] CUNY Coll Staten Isl, Dept Biol, Staten Isl, NY USA
[3] CUNY Coll Staten Isl, Neurosci Program, Staten Isl, NY USA
[4] CUNY Coll Staten Isl, Dept Chem, Staten Isl, NY USA
[5] Harvard Univ, Sch Med, Brigham & Womens Hosp, Dept Med,Div Expt Med & Hematol Oncol, Boston, MA USA
来源：
JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION | 2004年 / 24卷 / 1-2期
关键词：
F11; receptor; F11R; junctional adhesion molecule; JAM; JAM-1; JAM-A; PI-3; kinase; calcium ions; platelet aggregation; cell adhesion molecule (CAM); F11 receptor dimerization; integrin GPIIIa;
D O I：
10.1081/RRS-120034252
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The F11 receptor (F11R) (a.k.a. Junctional Adhesion Molecule, JAM) was first identified in human platelets as a 32/35 kDa protein duplex that serves as receptor for a functional monoclonal antibody that activates platelets. We have sequenced and cloned the F11R and determined that it is a member of the immunoglobulin (Ig) superfamily of cell adhesion molecules. The signaling pathways involved in F11R-induced platelet activation were examined in this investigation. The binding of M.Ab.F11 to the platelet F11R resulted in granule secretion and aggregation.
引用
收藏
页码：85 / 105
页数：21
相关论文
共 43 条
  • [21] F11-receptor (F11R/JAM) mediates platelet adhesion to inflamed endothelial cells.
    Babinska, A
    Kedees, MH
    Athar, H
    Ahmed, T
    Batuman, O
    Ehrlich, YH
    Hussain, MM
    Kornecki, E
    BLOOD, 2002, 100 (11) : 258A - 258A
  • [22] F11R/JAM-A: why do platelets express a molecule which is also present in tight junctions?
    Kamola, Piotr
    Babinska, Anna
    Przygodzki, Tomasz
    PLATELETS, 2023, 34 (01)
  • [23] F11-receptor (F11R/JAM) mediates platelet adhesion to endothelial cells: Role in inflammatory thrombosis
    Babinska, A
    Kedees, MH
    Athar, H
    Ahmed, T
    Batuman, C
    Ehrlich, YH
    Hussain, MM
    Kornecki, E
    THROMBOSIS AND HAEMOSTASIS, 2002, 88 (05) : 843 - 850
  • [24] A peptide antagonist of F11R/JAM-A reduces plaque formation and prolongs survival in an animal model of atherosclerosis
    Babinska, Anna
    Clement, Cristina C.
    Przygodzki, Tomasz
    Talar, Marcin
    Li, Yan
    Braun, Marcin
    Wzorek, Joanna
    Swiatkowska, Maria
    Ehrlich, Yigal H.
    Kornecki, Elizabeth
    Watala, Cezary
    Salifu, Moro O.
    ATHEROSCLEROSIS, 2019, 284 : 92 - 101
  • [25] Triple negative breast cancer metastasis is hindered by a peptide antagonist of F11R/JAM-A protein
    Bednarek, Radoslaw
    Wojkowska, Dagmara W.
    Braun, Marcin
    Watala, Cezary
    Salifu, Moro O.
    Swiatkowska, Maria
    Babinska, Anna
    CANCER CELL INTERNATIONAL, 2023, 23 (01)
  • [26] PEPTIDES INHIBITORS OF F11R/JAM-A ADHESION MOLECULES AND POTENT ANTI-ATHEROSCLEOSIS DRUGS
    Clement, C.
    Babinska, A.
    Ehrlich, Y.
    Philipp, M.
    Kornecki, E.
    BIOPOLYMERS, 2009, 92 (04) : 356 - 356
  • [27] Junctional Adhesion Molecule-A/F11 Receptor (JAM-A/F11R) Is a Novel Biomarker and a Potential Treatment-Target In Multiple Myeloma Tumor and Its Microvascular Milieu
    Azari, Bani M.
    Joseph, Danielle F.
    Braunstein, Marc J.
    Klueppelberg, H. Uwe
    Smith, Eric L. P.
    Scott, Sadeaqua
    Marmur, Jonathan D.
    Babinska, Anna
    Bauman, Olcay
    BLOOD, 2010, 116 (21) : 202 - 202
  • [28] F11R/JAM-a is required for platelet adhesion to inflamed endothelial cells (EC): role in thrombogenesis and atherosclerosis
    Azari, B. M.
    Marmur, J. D.
    Kornecki, E.
    Ehrlich, Y. H.
    Salifu, M. O.
    Babinska, A.
    JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2009, 7 : 302 - 302
  • [29] Interaction between platelet F11R/JAM-A and its immobilised counterpart switches the platelets adhering to fibrin from retracting to migrating phenotype
    Przygodzki, Tomasz
    Kamola, Piotr
    Watala, Cezary
    Salifu, Moro O.
    Babinska, Anna
    ACTA PHYSIOLOGICA, 2024, 240 : 51 - 51
  • [30] Triple negative breast cancer metastasis is hindered by a peptide antagonist of F11R/JAM‑A protein
    Radosław Bednarek
    Dagmara W. Wojkowska
    Marcin Braun
    Cezary Watala
    Moro O. Salifu
    Maria Swiatkowska
    Anna Babinska
    Cancer Cell International, 23
12345