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Whole-Brain Atrophy as a Measure of Progression in Premanifest and Early Huntington's Disease

被引：36
|
作者：
Henley, Susie M. D. [1 ]
Wild, Edward J. [1 ]
Hobbs, Nicola Z. [1 ]
Frost, Chris [1 ,2 ]
MacManus, David G. [3 ]
Barker, Roger A. [4 ]
Fox, Nick C. [1 ]
Tabrizi, Sarah J. [5 ]
机构：
[1] UCL, Inst Neurol, Dementia Res Ctr, London, England
[2] London Sch Hyg & Trop Med, Med Stat Unit, London WC1, England
[3] UCL, Inst Neurol, NMR Res Unit, London, England
[4] Addenbrookes Hosp, Brain Repair Ctr, Dept Clin Neurosci, Cambridge, England
[5] UCL, Inst Neurol, Dept Neurodegenerat Dis, London, England
来源：
MOVEMENT DISORDERS | 2009年 / 24卷 / 06期
关键词：
Huntington's disease; MRI; CAG repeat length; longitudinal; CLINICAL-TRIALS; MATTER LOSS; CAG REPEAT; LENGTH; MRI; VALIDATION;
D O I：
10.1002/mds.22485
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Therapeutic trials in Huntington's disease (HD) are challenging as clinical progression is slow and variable and reliable biomarkers are lacking. We used magnetic resonance imaging and the brain boundary shift integral to quantify whole-brain atrophy rates over 1 year in early and premanifest HD subjects, and controls. Early HD subjects had statistically significantly (P = 0.007) increased (threefold higher) rates of whole-brain atrophy compared with controls. Higher atrophy rates were associated with longer CAG repeat length. MRI-based measures of whole-brain atrophy may have potential as a measure of progression in HD. (C) 2009 Movement Disorder Society
引用
收藏
页码：932 / 936
页数：5
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