The renin-angiotensin system and aging in the kidney

被引：59
|
作者：
Yoon, Hye Eun
Choi, Bum Soon
机构：
[1] Division of Nephrology, Department of Internal Medicine, The Catholic University of Korea College of Medicine, Seoul
来源：
KOREAN JOURNAL OF INTERNAL MEDICINE | 2014年 / 29卷 / 03期
基金：
新加坡国家研究基金会;
关键词：
CONVERTING-ENZYME INHIBITION; DOWN-REGULATION; ANTIAGING GENE; KLOTHO; SIRT1; ALDOSTERONE; MODEL; AGE; GLOMERULOSCLEROSIS; TRANSCRIPTION;
D O I：
10.3904/kjim.2014.29.3.291
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Aging is associated with progressive functional deterioration and structural changes in the kidney. Changes in the activity or responsiveness of the renin-angiotensin system (RAS) occur with aging. RAS changes predispose the elderly to various fluid and electrolyte imbalances as well as acute kidney injury and chronic kidney disease. Among the multiple pathways involved in renal aging, the RAS plays a central role. This review summarizes the association of the RAS with structural and functional changes in the aging kidney and age-related renal injury, and describes the underlying mechanisms of RAS-related renal aging. An improved understanding of the renal aging process may lead to better individualized care of the elderly and improved renal survival in age-related diseases.
引用
收藏
页码：291 / 295
页数：5
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