Schwann cell remyelination is not replaced by oligodendrocyte remyelination following ethidium bromide induced demyelination

被引：32
|
作者：
Gilson, JM [1 ]
Blakemore, WF [1 ]
机构：
[1] Univ Cambridge, Dept Vet Clin Med, Cambridge CB2 OES, England
来源：
NEUROREPORT | 2002年 / 13卷 / 09期
关键词：
remyelination; Schwann cells; oligodendrocytes; demyelination;
D O I：
10.1097/00001756-200207020-00027
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Demyelinated CNS axons can be remyelinated by Schwann cells. A recent study concluded that with time Schwann cell remyelination is replaced by oligodendrocyte remyelination [9]. To examine this, the extent of Schwann cell and oligodendrocyte remyelination at 4, 6.5 and 24 weeks was determined for ethidium bromide lesions made in the spinal cords of rats. Although the extent of oligodendrocyte remyelination increased with time there was no significant change in the amount of Schwann cell remyelination. This indicates that Schwann cell remyelination is stable and is not replaced by oligodendrocyte remyelination.
引用
收藏
页码：1205 / 1208
页数：4
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