A convenient one-pot synthesis of 2-benzimidazolyl-thioacetophenones and thiazolo[3,2-a]benzimidazoles

被引：24

作者：

Sarhan, AEAO ^{[1
]}

ElSherief, HAH ^{[1
]}

Mahmoud, AM ^{[1
]}

机构：

[1] ASSIUT UNIV,FAC SCI,DEPT CHEM,ASSIUT 71516,EGYPT

来源：

TETRAHEDRON | 1996年 / 52卷 / 31期

关键词：

D O I：

10.1016/0040-4020(96)00569-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

2-Mercaptobenzimidazole (1) reacts with aromatic ketones 2a-d in acidified acetic acid giving 2-benzimidazolylthioacetophenones 3a-d. which on cyclization yield thiazolo[3,2-a]benzimidazoles 4a-d. Acetylation of 3a,d gave the N-acetyl derivatives 5a,d. Cyclization of 3a-d or 5d in acetic anhydride or acetic anhydride/pyridine mixture afforded 6a-d. While reaction of 1 with aliphatic or alicyclic ketones gave directly 2,3-disubstituted thiazolo[3.2-a]benzimidazoles 7a-f and 8a-d respectively. Copyright (C) 1996 Elsevier Science Ltd

引用

页码：10485 / 10496

页数：12

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