Construction of Binuclear Benzimidazole-Fused Quinazolinones and Pyrimidinones Using Aryl Isocyanates as Building Blocks by Transition-Metal-Free C(sp2)-N Coupling

被引：12
|
作者：
Pham Duy Quang Dao [1 ]
Chan Sik Cho [1 ]
机构：
[1] Kyungpook Natl Univ, Dept Appl Chem, Daegu 41566, South Korea
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2020年 / 85卷 / 20期
基金：
新加坡国家研究基金会;
关键词：
FREE N-ARYLATION; MEDIATED ANNULATION; EFFICIENT SYNTHESIS; CATALYZED SYNTHESIS; METHODOLOGY; DERIVATIVES; CHEMISTRY; SCAFFOLD; ANALOGS; AMINES;
D O I：
10.1021/acs.joc.0c02067
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A class of binuclear N-fused hybrid scaffolds was constructed by the reaction of 2-(2-bromoaryl)- and 2-(2-bromovinyl)benzimidazoles with aryl isocyanates as building blocks in the presence of a base under microwave irradiation. A nucleophilic addition followed by an unprecedented transitionmetal-free C(sp(2))-N coupling is proposed as a reaction pathway of this green process.
引用
收藏
页码：13354 / 13362
页数：9
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