THE SYNTHESIS, ANTITUMOR ACTIVITY, AND SAR OF N-SUBSTITUTED γ-AMINOPROPYLSILATRANE DERIVATIVES

被引：9

作者：

Guo Ping ^{[1
]}

Wang Yue-Wu ^{[1
]}

Luo Xin-Tong ^{[1
]}

Qi Xiao-Lu ^{[1
]}

Hou Le-Ping ^{[1
]}

Xie Zi-Xin ^{[1
]}

Ye Fa-Qing ^{[1
]}

机构：

[1] Wenzhou Med Coll, Sch Pharm, Wenzhou 325035, Zhejiang, Peoples R China

来源：

PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS | 2014年 / 189卷 / 04期

关键词：

-Aminopropylsilatrane derivatives; structure-activity relationship (SAR); physiological activity; SILATRANES; GERMATRANES;

D O I：

10.1080/10426507.2013.829835

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

-Aminopropylsilatrane has been reported to possess biological activity against tumor cancer cells with low cytotoxicity in many kinds of silatranes. So some N-substituted -aminopropylsilatrane derivatives were synthesized and assayed by a primary anticancer screening against HT-29, Hela, and MDAMB435 cells by the use of the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) method. The structures of these derivatives were confirmed by H-1 NMR, electrospray ionization-mass spectrometry, and elemental analysis. The structure-activity relationship showed that the N-substituted derivatives exhibit better activity in which the -amino group of the silatrane is connected with stronger electron-withdrawing groups.

引用

页码：511 / 518

页数：8

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