Neurosteroid modulation of native and recombinant GABA(A) receptors

被引：85
|
作者：
Lambert, JJ
Belelli, D
HillVenning, C
Callachan, H
Peters, JA
机构：
[1] Department of Pharmacology and Clinical Pharmacology, University of Dundee, Ninewells Hospital and Medical School
来源：
CELLULAR AND MOLECULAR NEUROBIOLOGY | 1996年 / 16卷 / 02期
关键词：
pregnane steroids; neurosteroids; GABA(A) receptor; whole-cell patch-clamp; Xenopus laevis oocyte; ligand-gated ion channel; anesthetic; neurotransmitter receptor; nongenomic steroid effects;
D O I：
10.1007/BF02088174
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
1. The pioneering work of Hans Selye over 50 years ago demonstrated that certain steroid metabolites can produce a rapid depression of central nervous system activity. 2. Research during the last 10 years has established that such effects are mediated by a nongenomic and specific interaction of these steroids with the brain's major inhibitory receptor, the GABA(A) receptor. 3. Here we describe the molecular mechanism of action of such steroids and review attempts to define the steroid binding site on the receptor protein. The therapeutic potential of such neurosteroids is discussed.
引用
收藏
页码：155 / 174
页数：20
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