Detection of Oligonucleotides Based on Terahertz Spectroscopy and Microstructure

被引：0

作者：

Tang, Mingjie ^{[1
]}

Zhang, Mingkun ^{[1
]}

Yan, Shihan ^{[1
]}

Xia, Liangping ^{[1
]}

Yang, Zhongbo ^{[1
]}

Wei, Dongshan ^{[1
]}

Cui, Hong-Liang ^{[1
]}

Du, Chunlei ^{[1
]}

机构：

[1] Chinese Acad Sci, Chongqing Inst Green & Intelligent Technol, Chongqing Key Lab Multiscale Mfg Technol, Chongqing 400714, Peoples R China

来源：

2016 6TH IEEE INTERNATIONAL CONFERENCE ON MANIPULATION, MANUFACTURING AND MEASUREMENT ON THE NANOSCALE (IEEE 3M-NANO) | 2016年

基金：

中国国家自然科学基金;

关键词：

terahertz spectroscopy; microstructure; base mutations; oligonucleotides; FIELD ENHANCEMENT; DNA; METAMATERIALS; NUCLEOTIDES;

D O I：

暂无

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

DNA mutations are analyzed by terahertz (THz) spectroscopy in a label-free manner. The 5 base mutations from the 3'-terminus on single stranded 17nt oligonucleotides have first been detected based on the microchannel. The mutations have also been validated based on the split-ring resonators (SRRs). The results clearly demonstrate the ability of THz spectroscopy combined with microstructure for label-free detection of base mutations of DNA biomolecules. This study has proved that the THz spectroscopy can be considered as a prospective diagnostic tool for studying the interaction of molecules such as DNA mutations.

引用

页码：35 / 38

页数：4

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