Use of a potent and selective highly constrained peptide agonist to design de novo an equally potent and selective non-peptide mimetic for the δ-opioid receptor

被引:0
|
作者
Hruby, VJ [1 ]
Liao, S [1 ]
Shenderovich, MD [1 ]
Alfaro-Lopez, J [1 ]
Hosohata, K [1 ]
Davis, P [1 ]
Porreca, F [1 ]
Yamamura, HI [1 ]
机构
[1] Univ Arizona, Dept Chem, Tucson, AZ 85721 USA
关键词
D O I
暂无
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
引用
收藏
页码:144 / 145
页数:2
相关论文
共 50 条
  • [21] Parametrization, conformational analysis of selective non-peptide δ-opioid ligands and simulation of their binding to δ- opioid receptor.
    Poda, GI
    Subramanian, G
    Ferguson, DM
    BIOPHYSICAL JOURNAL, 1999, 76 (01) : A113 - A113
  • [22] Potent and selective peptide agonists for human melanocortin receptor 5
    Bednarek, Maria A.
    MacNeil, Tanya
    Tang, Rui
    Cabello, M. Angeles
    Maroto, Marta
    Teran, Ana
    PEPTIDES FOR YOUTH, 2009, 611 : 95 - 96
  • [23] Use of X-ray co-crystal structures and molecular modeling to design potent and selective non-peptide inhibitors of cathepsin K
    DesJarlais, RL
    Yamashita, DS
    Oh, HJ
    Uzinskas, IN
    Erhard, KF
    Allen, AC
    Haltiwanger, RC
    Zhao, BG
    Smith, WW
    Abdel-Meguid, SS
    D'Alessio, K
    Janson, CA
    McQueney, MS
    Tomaszek, TA
    Levy, MA
    Veber, DF
    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1998, 120 (35) : 9114 - 9115
  • [24] From the First Selective Non-Peptide AT2 Receptor Agonist to Structurally Related Antagonists
    Murugaiah, A. M. S.
    Wu, Xiongyu
    Wallinder, Charlotta
    Mahalingam, A. K.
    Wan, Yiqian
    Skold, Christian
    Botros, Milad
    Guimond, Marie-Odile
    Joshi, Advait
    Nyberg, Fred
    Gallo-Payet, Nicole
    Hallberg, Anders
    Alterman, Mathias
    JOURNAL OF MEDICINAL CHEMISTRY, 2012, 55 (05) : 2265 - 2278
  • [25] De novo Design and Synthesis of Potent Antimicrobial Peptide and Mode of Action
    Yaraksa, Nualyai
    Daduang, Sakda
    CHIANG MAI JOURNAL OF SCIENCE, 2021, 48 (02): : 444 - 459
  • [26] NEUROPROTECTIVE ACTIONS OF GR89696, A HIGHLY POTENT AND SELECTIVE KAPPA-OPIOID RECEPTOR AGONIST
    BIRCH, PJ
    ROGERS, H
    HAYES, AG
    HAYWARD, NJ
    TYERS, MB
    SCOPES, DIC
    NAYLOR, A
    JUDD, DB
    BRITISH JOURNAL OF PHARMACOLOGY, 1991, 103 (03) : 1819 - 1823
  • [27] N-methylacetamide analog of salvinorin A:: A highly potent and selective κ-opioid receptor agonist with oral efficacy
    Beguin, Cecile
    Potter, David N.
    DiNieri, Jennifer A.
    Munro, Thomas A.
    Richards, Michele R.
    Paine, Tracie A.
    Berry, Loren
    Zhao, Zhiyang
    Roth, Bryan L.
    Xu, Wei
    Liu-Chen, Lee-Yuan
    Carlezon, William A., Jr.
    Cohen, Bruce M.
    JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2008, 324 (01): : 188 - 195
  • [28] μ Opioid receptor mutations confer agonist activity to non-peptide ligands and zinc
    Mathes, WF
    Ren, Y
    McBride, EW
    Beinborn, M
    Kopin, AS
    FASEB JOURNAL, 2001, 15 (05): : A897 - A897
  • [29] Prevention of isolation-induced hypertension with a non-peptide κ-opioid receptor agonist
    Wright, RC
    Ingenito, AJ
    BRITISH JOURNAL OF PHARMACOLOGY, 2000, 131 : U51 - U51
  • [30] Discovery of a potent, non-peptide bradykinin B1 receptor antagonist
    Su, DS
    Markowitz, MK
    DiPardo, RM
    Murphy, KL
    Harrell, CM
    O'Malley, SS
    Ransom, RW
    Chang, RSL
    Ha, S
    Hess, FJ
    Pettibone, DJ
    Mason, GS
    Boyce, S
    Freidinger, RM
    Bock, MG
    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2003, 125 (25) : 7516 - 7517