The copper-catalyzed N-arylation of indoles

被引：578
|
作者：
Antilla, JC [1 ]
Klapars, A [1 ]
Buchwald, SL [1 ]
机构：
[1] MIT, Dept Chem, Cambridge, MA 02139 USA
来源：
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2002年 / 124卷 / 39期
关键词：
D O I：
10.1021/ja027433h
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A general method for the N-arylation of indoles using catalysts derived from Cul and trans-1,2-cyclohexanediamine (1a), trans-N,N'-dimethyl-1,2-cyclohexanediamine (2a), or N,N'-dimethyl-ethylenediamine (3) is reported. N-Arylindoles can be produced in high yield from the coupling of an aryl iodide or aryl bromide with a variety of indoles.
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页码：11684 / 11688
页数：5
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