Regenerative Medicine for Epilepsy: From Basic Research to Clinical Application

被引：7

作者：

Yasuhara, Takao ^{[1
]}

Agari, Takashi ^{[1
]}

Kameda, Masahiro ^{[1
]}

Kondo, Akihiko ^{[1
]}

Kuramoto, Satoshi ^{[1
]}

Jing, Meng ^{[1
]}

Sasaki, Tatsuya ^{[1
]}

Toyoshima, Atsuhiko ^{[1
]}

Sasada, Susumu ^{[1
]}

Sato, Kenichiro ^{[1
]}

Shinko, Aiko ^{[1
]}

Wakamori, Takaaki ^{[1
]}

Okuma, Yu ^{[1
]}

Miyoshi, Yasuyuki ^{[1
]}

Tajiri, Naoki ^{[2
]}

Borlongan, Cesario V. ^{[2
]}

Date, Isao ^{[1
]}

机构：

[1] Okayama Univ, Dept Neurol Surg, Grad Sch Med, Okayama 7008558, Japan

[2] Univ S Florida, Coll Med, Dept Neurosurg, Tampa, FL 33612 USA

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2013年 / 14卷 / 12期

关键词：

brain-derived neurotrophic factor (BDNF); electrical stimulation; erythropoietin; GABAergic neuron; kainic acid; kindling; neural stem cell; TEMPORAL-LOBE EPILEPSY; VAGUS NERVE-STIMULATION; PLURIPOTENT STEM-CELLS; PARKINSONS-DISEASE; NEUROTROPHIC FACTOR; RAT MODEL; HIPPOCAMPAL NEURODEGENERATION; REFRACTORY EPILEPSY; PILOCARPINE MODEL; NEUROPEPTIDE-Y;

D O I：

10.3390/ijms141223390

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Epilepsy is a chronic neurological disorder, which presents with various forms of seizures. Traditional treatments, including medication using antiepileptic drugs, remain the treatment of choice for epilepsy. Recent development in surgical techniques and approaches has improved treatment outcomes. However, several epileptic patients still suffer from intractable seizures despite the advent of the multimodality of therapies. In this article, we initially provide an overview of clinical presentation of epilepsy then describe clinically relevant animal models of epilepsy. Subsequently, we discuss the concepts of regenerative medicine including cell therapy, neuroprotective agents, and electrical stimulation, which are reviewed within the context of our data.

引用

页码：23390 / 23401

页数：12

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