Decellularized xenografts in regenerative medicine: From processing to clinical application

被引：23

作者：

Capella-Monsonis, Hector ^{[1
,2
]}

Zeugolis, Dimitrios I. ^{[1
,2
,3
]}

机构：

[1] Natl Univ Ireland Galway NUI Galway, Regenerat Modular & Dev Engn Lab REMODEL, Biomed Sci Bldg, Galway, Ireland

[2] Natl Univ Ireland Galway NUI Galway, Sci Fdn Ireland SFI, Ctr Res Med Devices CURAM, Biomed Sci Bldg, Galway, Ireland

[3] Univ Svizzera Italiana USI, Regenerat Modular & Dev Engn Lab REMODEL, Fac Biomed Sci, Lugano, Switzerland

来源：

XENOTRANSPLANTATION | 2021年 / 28卷 / 04期

基金：

欧盟地平线“2020”; 爱尔兰科学基金会; 欧洲研究理事会;

关键词：

biomaterials; clinical products; decellularized xenografts; extracellular matrix; ACELLULAR DERMAL MATRIX; SMALL-INTESTINE SUBMUCOSA; URINARY-BLADDER MATRIX; PORCINE EXTRACELLULAR-MATRIX; ROTATOR CUFF TEARS; ELECTRON-BEAM STERILIZATION; BIOLOGIC SCAFFOLD MATERIALS; HUMAN UMBILICAL ARTERIES; MESENCHYMAL STEM-CELLS; CROSS-LINKING REAGENT;

D O I：

10.1111/xen.12683

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Decellularized xenografts are an inherent component of regenerative medicine. Their preserved structure, mechanical integrity and biofunctional composition have well established them in reparative medicine for a diverse range of clinical indications. Nonetheless, their performance is highly influenced by their source (ie species, age, tissue) and processing (ie decellularization, crosslinking, sterilization and preservation), which govern their final characteristics and determine their success or failure for a specific clinical target. In this review, we provide an overview of the different sources and processing methods used in decellularized xenografts fabrication and discuss their effect on the clinical performance of commercially available decellularized xenografts.

引用

页数：27

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