Directed Evolution and Rational Design Combined for Enhanced AAV Vectors

被引：0
|
作者：
Khabou, Hanen [1 ,2 ,3 ]
Barbe, Peggy [1 ,2 ,3 ]
Auregan, Gwenaelle [4 ,5 ]
Desrosiers, Melissa [1 ,2 ,3 ]
Bemelmans, Alexis-Pierre [4 ,5 ]
Dalkara, Deniz [1 ,2 ,3 ]
机构：
[1] INSERM, UMR S 968, Inst Vis, Paris, France
[2] Univ Paris 06, Sorbonne Univ, UMR S 968, Inst Vis, Paris, France
[3] CNRS, UMR 7210, Paris, France
[4] Commissariat Energie Atom & Energies Alternat CEA, DSV, Inst Imagerie Biomed I2BM, Mol Imaging Res Ctr MIRCen, Paris, France
[5] Commissariat Energie Atom & Energies Alternat CEA, DSV, Inst Imagerie Biomed I2BM, CNRS,URA2210, Paris, France
来源：
MOLECULAR THERAPY | 2014年 / 22卷
关键词：
D O I：
暂无
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
299
引用
收藏
页码：S115 / S115
页数：1
相关论文
共 50 条
  • [41] Nanobody-Enhanced Targeting of AAV Gene Therapy Vectors
    Eichhoff, Anna Marei
    Boerner, Kathleen
    Albrecht, Birte
    Schaefer, Waldemar
    Baum, Natalie
    Haag, Friedrich
    Koerbelin, Jakob
    Trepel, Martin
    Braren, Ingke
    Grimm, Dirk
    Adriouch, Sahil
    Koch-Nolte, Friedrich
    MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT, 2019, 15 : 211 - 220
  • [42] Fantastic AAV Gene Therapy Vectors and How to Find Them-Random Diversification, Rational Design and Machine Learning
    Becker, Jonas
    Fakhiri, Julia
    Grimm, Dirk
    PATHOGENS, 2022, 11 (07):
  • [43] Discovery of Novel AAV Capsids with Enhanced Skeletal Muscle Tropism Following Directed Evolution in Cynomolgus Macaque
    Jin, Quan
    Hung, Ka Ying Sharon
    Kashyap, Samneet
    Rouse, Emily
    Kelemen, Margaret
    Xiang, Lucia
    Utturkar, Aditya
    Chittoda, Misha
    Sampath, Harini
    Bourque, Shawn
    Desmarais, Samantha
    Deng, Shuyun
    Chen, Wei Tong
    Gianni, Davide
    Suh, Junghae
    Yuan, Yuan
    MOLECULAR THERAPY, 2023, 31 (04) : 556 - 556
  • [44] Directed evolution of AAV accounting for long-term and enhanced transduction of cardiovascular endothelial cells in vivo
    Liu, Y. B.
    Xu, B. C.
    Chen, Y. T.
    Yuan, X.
    Liu, J. Y.
    Liu, T.
    Du, G. Z.
    Jiang, W.
    Yang, Y.
    Zhu, Y.
    Chen, L. J.
    Ding, B. S.
    Wei, Y. Q.
    Yang, L.
    MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT, 2021, 22 : 148 - 161
  • [45] Gene therapy: Directed evolution of designer vectors
    Whalley, K
    NATURE REVIEWS DRUG DISCOVERY, 2006, 5 (03) : 188 - 189
  • [46] Directed evolution combined with rational design increases activity of GpdQ toward a non-physiological substrate and alters the oligomeric structure of the enzyme
    Yip, Sylvia H-C.
    Foo, Jee-Loon
    Schenk, Gerhard
    Gahan, Lawrence R.
    Carr, Paul D.
    Ollis, David L.
    PROTEIN ENGINEERING DESIGN & SELECTION, 2011, 24 (12): : 861 - 872
  • [47] Thermostability Enhancement of GH 62 α-l-Arabinofuranosidase by Directed Evolution and Rational Design
    Martins, Manoela
    dos Santos, Alberto M.
    da Costa, Clauber H. S.
    Canner, Samuel W.
    Chungyoun, Michael
    Gray, Jeffrey J.
    Skaf, Munir S.
    Ostermeier, Marc
    Goldbeck, Rosana
    JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2024, 72 (08) : 4225 - 4236
  • [48] Synthetic Biology, Directed Evolution, and the Rational Design of New Cardiovascular Therapeutics Are We There Yet?
    Mann, Douglas L.
    JACC-BASIC TO TRANSLATIONAL SCIENCE, 2023, 8 (07): : 905 - 906
  • [49] BIOT 300-Engineering cellulases on their natural substrates by directed evolution and rational design
    Liu, Wenjin
    Zhang, Xiaozhou
    Zhang, Zuoming
    Zhang, Y-H. Percival
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2009, 238
  • [50] Engineering proteins for thermostability: the use of sequence alignments versus rational design and directed evolution
    Lehmann, M
    Wyss, M
    CURRENT OPINION IN BIOTECHNOLOGY, 2001, 12 (04) : 371 - 375
12345