Epithalon inhibits tumor growth and expression of HER-2/neu oncogene in breast tumors in transgenic mice characterized by accelerated aging

被引：3
|
作者：
Anisimov, VN
Khavinsov, VK
Alimova, IN
Provintsiali, M
Manchini, R
Francheski, K
机构：
[1] Russian Acad Med Sci, St Petersburg Inst Bioregulat & Gerontol, NW Div, Moscow 109801, Russia
[2] Russian Minist Hlth, NN Petrov Inst Oncol, Dept Carcinogenesis & Oncogerontol, St Petersburg, Russia
[3] Italian Natl Res Ctr Aging, Ancona, Italy
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2002年 / 133卷 / 02期
关键词：
transgenic mice; HER-2/neu; breast cancer; peptides; Epithalon; Vilon;
D O I：
10.1023/A:1015555023692
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Female transgenic FVB mice carrying breast cancer gene HER-2/neu were monthly injected with Vilon or Epithalon (1 mug subcutaneously for 5 consecutive days) starting from the 2nd month of life. Epithalon markedly inhibited neoplasm development: the maximum size of breast adenacarcinomas was 33% lower than in the control (p<0.05). The intensity of HER-2/neu mRNA expression in breast tumors of Epithalon-treated mice was 3.7 times lower than in control animals. These results indicate that Epithalon inhibited breast tumor development in transgenic mice, which is probably related to suppression of HER-2/neu expression.
引用
收藏
页码：167 / 170
页数：4
相关论文
共 50 条
  • [31] Diindolylmethane (DIM), a naturally occurring compound found in cruciferous vegetables, reduces HER-2/Neu signaling and retards mammary tumor growth in HER-2/Neu transgenic mice.
    McGuire, K
    Burd, R
    Ngoubilly, N
    Lanza-Jacoby, S
    [J]. CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, 2005, 14 (11) : 2718S - 2719S
  • [32] Tumor suppressor ARF inhibits HER-2/neu-mediated oncogenic growth
    Yujiang Zhang
    Heng-Yin Yang
    Xiao-Chun Zhang
    Huiling Yang
    Mayli Tsai
    Mong-Hong Lee
    [J]. Oncogene, 2004, 23 : 7132 - 7143
  • [33] Expression of HER-2/neu oncogene in normal, hyperplastic and malignant endometrium
    Rasty, G
    Murray, R
    Lu, L
    Kubilis, P
    Benrubi, G
    Masood, S
    [J]. ANNALS OF CLINICAL AND LABORATORY SCIENCE, 1998, 28 (03): : 138 - 143
  • [34] Vaccination by genetically modified dendritic cells expressing the HER-2/neu oncogene prevents development of spontaneous breast cancer in transgenic mice
    Sakai, Y
    Morrison, B
    Burke, J
    Janik, J
    Terabe, M
    Park, JM
    Forni, G
    Berzofsky, J
    Morris, J
    [J]. JOURNAL OF IMMUNOTHERAPY, 2003, 26 (06): : S13 - S14
  • [35] Determining HER-2/neu expression in breast carcinoma
    Vang, R
    Abrams, J
    [J]. LABORATORY INVESTIGATION, 1999, 79 (01) : 194A - 194A
  • [36] HER-2/NEU ONCOGENE EXPRESSION AND PROGNOSIS IN GASTRIC-CARCINOMA
    LEE, EY
    CIBULL, ML
    STRODEL, WE
    HALEY, J
    [J]. LABORATORY INVESTIGATION, 1992, 66 (01) : A44 - A44
  • [37] Tumor suppressor ARF inhibits HER-2/neu-mediated oncogenic growth
    Zhang, YJ
    Yang, HY
    Zhang, XC
    Yang, HL
    Tsai, ML
    Lee, MH
    [J]. ONCOGENE, 2004, 23 (42) : 7132 - 7143
  • [38] Analysis of mammary carcinoma onset and progression in HER-2/neu oncogene transgenic mice reveals a lobular origin
    Di Carlo, E
    Diodoro, MG
    Boggio, K
    Modesti, A
    Modesti, M
    Nanni, P
    Forni, G
    Musiani, P
    [J]. LABORATORY INVESTIGATION, 1999, 79 (10) : 1261 - 1269
  • [39] Expression of HER-2/neu receptor protein in adrenal tumors
    Saeger, W
    Fassnacht, M
    Reincke, M
    Allolio, B
    [J]. PATHOLOGY RESEARCH AND PRACTICE, 2002, 198 (07) : 445 - 448
  • [40] Effect of annatto-tocotrienols supplementation on the development of mammary tumors in HER-2/neu transgenic mice
    Pierpaoli, Elisa
    Viola, Valentina
    Barucca, Alessandra
    Orlando, Fiorenza
    Galli, Francesco
    Provinciali, Mauro
    [J]. CARCINOGENESIS, 2013, 34 (06) : 1352 - 1360
12345