Epithalon inhibits tumor growth and expression of HER-2/neu oncogene in breast tumors in transgenic mice characterized by accelerated aging

被引：3
|
作者：
Anisimov, VN
Khavinsov, VK
Alimova, IN
Provintsiali, M
Manchini, R
Francheski, K
机构：
[1] Russian Acad Med Sci, St Petersburg Inst Bioregulat & Gerontol, NW Div, Moscow 109801, Russia
[2] Russian Minist Hlth, NN Petrov Inst Oncol, Dept Carcinogenesis & Oncogerontol, St Petersburg, Russia
[3] Italian Natl Res Ctr Aging, Ancona, Italy
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2002年 / 133卷 / 02期
关键词：
transgenic mice; HER-2/neu; breast cancer; peptides; Epithalon; Vilon;
D O I：
10.1023/A:1015555023692
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Female transgenic FVB mice carrying breast cancer gene HER-2/neu were monthly injected with Vilon or Epithalon (1 mug subcutaneously for 5 consecutive days) starting from the 2nd month of life. Epithalon markedly inhibited neoplasm development: the maximum size of breast adenacarcinomas was 33% lower than in the control (p<0.05). The intensity of HER-2/neu mRNA expression in breast tumors of Epithalon-treated mice was 3.7 times lower than in control animals. These results indicate that Epithalon inhibited breast tumor development in transgenic mice, which is probably related to suppression of HER-2/neu expression.
引用
收藏
页码：167 / 170
页数：4
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