Stereodivergent Synthesis of 17-α and 17-β-Aryl Steroids: Application and Biological Evaluation of D-Ring Cortistatin Analogues

被引：52

作者：

Shi, Jun ^{[1
]}

Shigehisa, Hiroki ^{[1
]}

Guerrero, Carlos A. ^{[1
]}

Shenvi, Ryan A. ^{[1
]}

Li, Chuang-Chuang ^{[1
]}

Baran, Phil S. ^{[1
]}

机构：

[1] Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2009年 / 48卷 / 24期

关键词：

angiogenesis; asymmetric synthesis; natural products; CATALYTIC HYDROGENOLYSIS; CONCISE SYNTHESIS; ALKALOIDS; STEREOCHEMISTRY; HYDROGENATION; ALCOHOLS;

D O I：

10.1002/anie.200901116

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

One stereocenter makes all the difference: The synthesis and biological evaluation of 17-epi-cortistatin A is reported from a common intermediate used to procure natural cortistatin A. The synthesis features a unique stereocontrolled Raney-Ni reduction process that can be employed to reliably produce both α- and β-configured Dring aryl steroids. Biological evaluations of these "cortalogs" are reported for the first time. © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：4328 / 4331

页数：4

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