MicroRNA regulation of cancer stem cells in the pathogenesis of breast cancer

被引：20
|
作者：
Niu, Tong [1 ,2 ,3 ]
Zhang, Weiwei [1 ,2 ]
Xiao, Wei [1 ,2 ,3 ]
机构：
[1] Capital Normal Univ, Beijing Key Lab DNA Damage Responses, Beijing 100048, Peoples R China
[2] Capital Normal Univ, Coll Life Sci, Beijing 100048, Peoples R China
[3] Univ Saskatchewan, Dept Biochem Microbiol & Immunol, Saskatoon, SK S7N 5E5, Canada
来源：
CANCER CELL INTERNATIONAL | 2021年 / 21卷 / 01期
基金：
中国国家自然科学基金;
关键词：
Breast cancer; Breast cancer stem cell (BCSC); miRNA; Self-renewal; Therapeutic resistance;
D O I：
10.1186/s12935-020-01716-8
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Breast cancer is the most common cancer among women and accounts for 30% of all female malignancies worldwide. Breast cancer stem cells (BCSCs) are a small population of breast cancer cells that exhibit multiple characteristics including differentiation capacity, self-renewal and therapeutic resistance. Recently, BCSCs have attracted attention due to their modulation of breast tumor behaviors and drug resistance. miRNAs are small noncoding mRNAs involved in virtually all biological processes, including stem cell development, maintenance and differentiation. In breast cancer, miRNAs appear to be multi-faceted since they can act as either suppressors or oncogenes to regulate breast cancer progression. This review summarizes the critical roles of miRNAs in regulating multiple signaling pathways such as Wnt/beta -catenin, Notch, PI3K/AKT/mTOR, BMI-1 and STAT3 that are important for the BCSC maintenance.
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收藏
页数：14
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