Analysis of an HIV/AIDS treatment model with a nonlinear incidence

An HIV/AIDS treatment model with a nonlinear incidence is formulated. The infectious period is partitioned into the asymptotic and the symptomatic phases according to clinical stages. The constant recruitment rate, disease-induced death, drug therapies, as well as a nonlinear incidence, are incorporated into the model. The basic reproduction number R(0) of the model is determined by the method of next generation matrix. Mathematical analysis establishes that the global dynamics of the spread of the HIV infectious disease are completely determined by the basic reproduction number R(0). If R(0) <= 1, the disease always dies out and the disease-free equilibrium is globally stable. If R(0) > 1, the disease persists and the unique endemic equilibrium is globally asymptotically stable in the interior of the feasible region. (C) 2007 Elsevier Ltd. All rights reserved.