Echinacea purpurea for prevention of experimental rhinovirus colds

被引:47
|
作者
Sperber, SJ
Shah, LP
Gilbert, RD
Ritchey, TW
Monto, AS
机构
[1] Hackensack Univ, Med Ctr, Div Infect Dis, Dept Internal Med, Hackensack, NJ 07601 USA
[2] Univ Med & Dent New Jersey, New Jersey Med Sch, Newark, NJ 07103 USA
[3] TKL Res, Paramus, NJ USA
[4] Univ Michigan, Sch Publ Hlth, Dept Epidemiol, Ann Arbor, MI 48109 USA
关键词
D O I
10.1086/386324
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
A randomized, double- blind, placebo-controlled clinical trial was conducted to evaluate the ability of Echinacea purpurea to prevent infection with rhinovirus type 39 (RV-39). Forty-eight previously healthy adults received echinacea or placebo, 2.5 mL 3 times per day, for 7 days before and 7 days after intranasal inoculation with RV-39. Symptoms were assessed to evaluate clinical illness. Viral culture and serologic studies were performed to evaluate the presence of rhinovirus infection. A total of 92% of echinacea recipients and 95% of placebo recipients were infected. Colds developed in 58% of echinacea recipients and 82% of placebo recipients (P = .114, by Fisher's exact test). Administration of echinacea before and after exposure to rhinovirus did not decrease the rate of infection; however, because of the small sample size, statistical hypothesis testing had relatively poor power to detect statistically significant differences in the frequency and severity of illness.
引用
收藏
页码:1367 / 1371
页数:5
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