γδ T-cell lymphoma:: a clinicopathologic study of 6 cases including extrahepatosplenic type

被引:0
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作者
Yamaguchi, M
Ohno, T
Nakamine, H
Oka, K
Matsuzuka, F
Miwa, H
Shiku, H
Kimura, N
Nanba, K
Kita, K
机构
[1] Mie Univ, Sch Med, Dept Internal Med 2, Tsu, Mie 5148507, Japan
[2] Kuma Hosp, Kobe, Hyogo, Japan
[3] Wakayama Med Univ, Dept Lab Med, Wakayama, Japan
[4] Fukuoka Univ, Sch Med, Dept Internal Med 1, Fukuoka, Japan
[5] Hiroshima Univ, Fac Integrated Arts & Sci, Hiroshima 730, Japan
关键词
non-Hodgkin's lymphoma; gamma delta T cell; autoimmune disease; immunohistochemistry;
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
We report 6 cases of gamma delta T-cell lymphoma (GDTL) among 115 peripheral T-cell lymphomas over a 12-year period. All patients exhibited extranodal lymphomas, comprising 3 hepatosplenic. 1 cutaneous, 1 intestinal, and 1 thyroidal lymphoma. Despite therapies. all bur 1 patient died of disease within 16 months of diagnosis. The cytologic features of lymphoma cells in 3 of 5 cases examined were very similar: coarsely reticulated nuclear chromatin, multiple small nucleoli, abundant faintly eosinophilic granular cytoplasm, and focal angiocentric proliferation. All 6 lymphomas showed CD3(+)CD4(-)CD8(-/+) phenotype. CD56 was positive in 3 cases, 1 of which was also CD16 positive. Perforin and T-cell intracellular antigen-1 were positive in all 5 cases examined. Southern blot analysis revealed clonal gene rearrangements of the T-cell receptor delta-chain gene in all 5 cases examined. Based on these findings, together with a review of the literature, GDTLs seem to have several common lineage-specific features, although clinical presentation and course of GDTL ale heterogenous. (C) 1995, The Japanese Society of Hematology.
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收藏
页码:186 / 195
页数:10
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