Lysophosphatidylglycerol inhibits formyl peptide receptor like-1-stimulated chemotactic migration and IL-1β production from human phagocytes

被引：16
|
作者：
Shim, Jae Woong [1 ]
Jo, Seong Ho [1 ]
Kim, Sang Doo [1 ]
Lee, Ha Young [1 ]
Yun, Jeanho [1 ]
Bae, Yoe-Sik [1 ]
机构：
[1] Dong A Univ, Dept Biochem, Coll Med, Pusan 602714, South Korea
来源：
EXPERIMENTAL AND MOLECULAR MEDICINE | 2009年 / 41卷 / 08期
关键词：
cell migration inhibition; chemotaxis; leukocyte; interleukin-1; beta; lysophosphatidylglycerol; phagocytes; receptors; formyl peptide; PROTEIN-COUPLED RECEPTOR; OVARIAN-CANCER CELLS; NF-KAPPA-B; PHOSPHOLIPASE A(2); RESPIRATORY BURST; HUMAN NEUTROPHILS; HUMAN MONOCYTES; IDENTIFICATION; FPRL1; ACID;
D O I：
10.3858/emm.2009.41.8.064
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
In this study, we observed that lysophosphatidylglycerol (LPG) completely inhibited a formyl peptide receptor like-1 (FPRL1) agonist (MMK-1)-stimulated chemotactic migration in human phagocytes, such as neutrophils and monocytes. LPG also dramatically inhibited IL-1 beta production by another FPRL1 agonist serum amyloid A (SAA) in human phagocytes. However, LPG itself induced intracellular calcium increase and superoxide anion production in human phagocytes. Keeping in mind that phagocytes migration and IL-1 beta production by FPRL1 are important for the induction of inflammatory response, our data suggest that LPG can be regarded as a useful material for the modulation of inflammatory response induced by FPRL1 activation.
引用
收藏
页码：584 / 591
页数：8
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