Asymmetric synthesis of stable α-aminoboronic esters catalyzed by N-heterocylic carbene and copper(I) chloride

被引：13
|
作者：
Chen, Jinbo [1 ]
Chen, Ling-yan [1 ]
Zheng, Yue [1 ]
Sun, Zhihua [1 ]
机构：
[1] Shanghai Univ Engn Sci, Coll Chem & Chem Engn, Shanghai 201620, Peoples R China
来源：
RSC ADVANCES | 2014年 / 4卷 / 40期
关键词：
DIPEPTIDYL PEPTIDASE-IV; AMINO BORONATE ESTERS; PROTEASOME INHIBITORS; LIGANDS; ACTIVATION; ALDIMINES; COMPLEX; TARGET; CANCER; BOND;
D O I：
10.1039/c4ra02229g
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Bis(pinanediolato)diboron (B(2)pnd(2)) was used as the nucleophile instead of bis(pinacolato)diboron in the stereospecific synthesis of alpha-aminoboronic esters catalysed by a triazole-based N-hetereocyclic carbene (NHC) and Cu(I) chloride. The resulting pinanediol-protected alpha-aminoboronic esters have significantly improved stability over the pinacol derivatives.
引用
收藏
页码：21131 / 21133
页数：3
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