Interleukin-35 takes the 'B' line

被引：20

作者：

Mauri, Claudia ^{[1
]}

Nistala, Kiran ^{[1
]}

机构：

[1] UCL, Div Med, Ctr Rheumatol, London, England

来源：

NATURE MEDICINE | 2014年 / 20卷 / 06期

关键词：

CELLS; AUTOIMMUNITY; CONTRIBUTES; IMMUNITY;

D O I：

10.1038/nm.3594

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Regulatory B cells exert an immunosuppressive role by secreting the cytokine interleukin-10 (IL-10). Two studies have now identified B cell derived IL-35 as both an inducer and a mediator of regulatory B cell function. IL-35 switched off inflammation in mouse models of autoimmunity, whereas its absence in B cells in mice enhanced survival after Salmonella enterica serovar Typhimurium infection. IL-35 could therefore be targeted for treating human autoimmune and infectious disease.

引用

页码：580 / 581

页数：2

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