Prevention of cisplatin-induced delayed emesis: still unsatisfactory

被引：0
|
作者：
Ruggeri, B
Ballatori, E
Roila, F [1 ]
De Angelis, V
Tonato, M
Del Favero, A
Ciccarese, G
Basurto, C
Ciccarese, G
Palladino, MA
Porrozzi, S
Picciafuoco, M
Contu, SA
Olmeo, N
Pazzola, A
Pilo, L
Tateo, PS
Salamano, S
Morana, S
Lucchino, S
Ricci, S
Antonuzzo, A
Allegrini, G
Galli, L
Conte, PF
Massidda, B
Ionta, MT
Scanu, A
Murru, R
Picece, V
Nicodemo, M
Recaldin, E
Nuzzo, A
Laudadio, L
D'Ostilio, N
Locatelli, MC
D'Antona, A
Luporini, G
Scagliotti, G
Selvaggi, G
Mattei, A
Favalli, G
Gambino, A
Fava, S
Grimi, E
Fava, S
Grimi, E
Scarfone, G
Bolis, MC
Alessandroni, P
机构：
[1] Policlin Hosp, Div Med Oncol, I-06122 Perugia, Italy
[2] Univ Aquila, Dept Internal Med & Publ Hlth, Med Stat Unit, I-67100 Laquila, Italy
[3] Univ Perugia, Dept Internal Med & Oncol Sci, I-06100 Perugia, Italy
来源：
SUPPORTIVE CARE IN CANCER | 2000年 / 8卷 / 03期
关键词：
delayed emesis; cisplatin; antiemetics;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The incidence of and prognostic factors in cisplatin-induced delayed emesis were evaluated in 522 naive cancer patients. They each received an intravenous combination of ondansetron and one of four different doses of dexamethasone for the prevention of acute emesis and a combination of orally administered metoclopramide plus intramuscular dexamethasone for the prevention of delayed emesis. Despite the best prophylaxis for acute and delayed emesis, 37.4% / 57.1% of patients experienced delayed vomiting / nausea. The presence of acute vomiting / nausea was the main prognostic factor in delayed vomiting / nausea; therefore, a multifactorial analysis of the results achieved during the delayed phase adjusted for those obtained during the acute phase should be carried out in every study evaluating the efficacy of different antiemetic drugs for delayed emesis.
引用
收藏
页码：229 / 232
页数：4
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