Synthetic studies toward the marine metabolite prorocentin-4: synthesis of the C1-C23 fragment

被引：2

作者：

AnkiReddy, Praveen ^{[1
]}

AnkiReddy, Sandeep ^{[1
]}

Gowravaram, Sabitha ^{[1
]}

机构：

[1] Indian Inst Chem Technol, CSIR, Nat Prod Chem Div, Hyderabad 500607, India

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2018年 / 16卷 / 22期

关键词：

ASYMMETRIC EPOXIDATION; ALCOHOLS; POLYKETIDE;

D O I：

10.1039/c8ob00388b

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A synthetic study of the construction of the C1-C23 fragment of prorocentin-4, a novel linear polyketide, is described. The synthetic highlights include the acid catalyzed epoxide opening, Gilman reaction, Pd(OH)(2) catalyzed transformation of a primary propargylic alcohol into an aldehyde, Oxa-Michael cyclization, and Horner-Wadsworth-Emmons (HWE) olefination reaction as key steps.

引用

页码：4191 / 4194

页数：4

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