Humoral and cell-mediated immune responses in DNA immunized mink challenged with wild-type canine distemper virus

被引：10
|
作者：
Nielsen, Line [1 ]
Sogaard, Mette [1 ]
Karlskov-Mortensen, Peter [1 ]
Jensen, Trine Hammer [1 ]
Jensen, Tove Dannemann [1 ]
Aasted, Bent [1 ]
Blixenkrone-Moller, Merete [1 ]
机构：
[1] Univ Copenhagen, Fac Life Sci, Dept Vet Dis Biol, DK-1870 Frederiksberg C, Denmark
来源：
VACCINE | 2009年 / 27卷 / 35期
关键词：
Canine distemper virus; DNA vaccination; Immunity; MONOCLONAL-ANTIBODIES; VACCINATED DOGS; DISEASE PARVOVIRUS; MATERNAL ANTIBODY; POXVIRUS VACCINES; LYMPHOID-TISSUES; RHESUS MACAQUES; CDV INFECTION; H PROTEINS; HEMAGGLUTININ;
D O I：
10.1016/j.vaccine.2009.05.090
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The aim of the study was to investigate the different phases of the immune response after DNA immunization with the hemagglutinin and nucleoprotein genes from canine distemper virus (CDV). Although attenuated live CDV vaccines have effectively reduced the incidence of disease, canine distemper is still a problem worldwide. The broad host range of CDV creates a constant viral reservoir among wildlife animals. Our results demonstrated early humoral and cell-mediated immune responses (IFN-gamma) in DNA vaccinated mink compared to mock-vaccinated mink after challenge with a Danish wild-type CDV. The DNA vaccine-induced immunity protected the natural host against disease development. (C) 2009 Elsevier Ltd. All rights reserved.
引用
收藏
页码：4791 / 4797
页数：7
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